Evidence map›Paper›PMID 41162467›Full record

ArticleScientific reports2025

Leishmania amazonensis infection induces PD-L1 expression on dendritic cells and impairs Th1 responses in vitro and in vivo.

Herbert Leonel de Matos Guedes, Alessandra Marcia da Fonseca-Martins, Yuejin Liang, Eric D Carlsen, Calvin A Henard, Irina V Pinchuk, Lynn Soong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. T cell exhaustion in parasitic infections.Frontiers in immunology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Herbert Leonel de Matos Guedes *Laboratório de Imunobiotecnologia, Grupo de Imunologia e Vacinologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. herbert@micro.ufrj.br.
Alessandra Marcia da Fonseca-Martins *Laboratório de Imunobiotecnologia, Grupo de Imunologia e Vacinologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Yuejin LiangDepartment of Microbiology and Immunology , University of Texas Medical Branch , Galveston, TX, USA.
Eric D CarlsenDepartment of Microbiology and Immunology , University of Texas Medical Branch , Galveston, TX, USA.
Calvin A HenardDepartment of Pathology , University of Texas Medical Branch , Galveston, TX, USA.
Irina V PinchukDepartment of Pathology , University of Texas Medical Branch , Galveston, TX, USA.
Lynn SoongDepartment of Microbiology and Immunology , University of Texas Medical Branch , Galveston, TX, USA. lysoong@utmb.edu.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico PQ-1D: 307632/2022-9Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/200.993/2022
6 · The paper itself

Abstract

Leishmania amazonensis is an etiological agent of diffuse cutaneous leishmaniasis in South America. In murine models, dysfunctional expansion of effector T cells and Th1 response exhaustion are linked to pathogenesis, while regulatory T cells (Tregs) promote lesion resolution. This study examined the roles of PD-1 and PD-L1 in the immunopathogenesis of L. amazonensis infection in C57BL/6 mice. We found a significant increase in PD-1 and PD-L1 expression in infected tissues, correlating with increased PD-L1

Indexed as

B7-H1 AntigenDendritic CellsLeishmania mexicanaLeishmaniasis, CutaneousTh1 CellsAnimalsFemaleMiceMice, Inbred C57BLMice, KnockoutProgrammed Cell Death 1 ReceptorSignal TransductionSTAT3 Transcription FactorTOR Serine-Threonine KinasesB7-H1 AntigenCd274 protein, mousePdcd1 protein, mouseProgrammed Cell Death 1 ReceptorSTAT3 Transcription FactorTOR Serine-Threonine KinasesLeishmania amazonensisLeishmaniasisPD-1PD-L1T cell exhaustion, dendritic cellsTh1

Identifiers

PMID41162467
PMCPMC12572114

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.