SynthesisScientific reports2025
Non-adherence with the treatment regimen and its associated factors among patients with schizophrenia in Sub-Saharan Africa: a systematic review and meta-analysis.
Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Effectiveness of the Systems Analysis and Improvement Approach to optimise outpatient mental, neurological, and substance-use disorder treatment cascades in Mozambique: a cluster-randomised trial.The lancet. Psychiatry · 2026Trial
- Digital and Biomarker-Based Monitoring for Schizophrenia-Treatment Adherence.Neuropsychopharmacology reports · 2026Review
- Article
- Beyond treatment non-adherence: A qualitative study of clinicians' perspectives on structural and social determinants of schizophrenia relapse in South Africa.Global mental health (Cambridge, England) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is among the serious mental illness affecting about 1% of the global population and ranking among the top ten causes of long-term disability. It is a major contributor to global disability and requires consistent adherence to antipsychotic medication for effective management. However, treatment non-adherence remains a significant challenge, particularly in Sub-Saharan Africa (SSA), where systemic barriers and cultural stigma further exacerbate the issue. This systematic review and meta-analysis aim to estimate the pooled prevalence of antipsychotic non-adherence among patients with schizophrenia in SSA and to identify the factors associated with treatment non-adherence. A systematic search was conducted across multiple databases, including PubMed, Cochrane, Scopus, African Index Medicus, and Google Scholar, for studies published before February 2025. This review has been registered with PROSPERO (registration number: CRD420251038674). Data were extracted using standardized forms, and study quality was assessed using the Joanna Briggs Institute (JBI) tools. A random-effects model was employed to estimate the pooled prevalence, with subgroup analyses and meta-regression conducted to explore sources of heterogeneity. This meta-analysis, which was conducted in SSA, included 16 full-text articles encompassing a total of 5,994 participants. The pooled prevalence of antipsychotic non-adherence was 45.30% (95% CI: 29.57-61.04%), with substantial heterogeneity observed (I
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.