Evidence map›Paper›PMID 41162372›Full record

ArticleNature communications2025

FAD synthase confers ferroptosis resistance and restrains CD8

Jiashuo Chao, Yuan Liang, Hao Wang, Ziyu Xun, Shanshan Wang, Zhengfeng Xuan, Mingming Wang, Qiyuan Huang, Rui Zhang, Mu Liu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Ferroptosis in liver biology and diseases.Hepatology communications · 2026
    Review
  2. Article
  3. BZW1 Drives Immune Evasion in Lung Adenocarcinoma via Ferroptosis Suppression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jiashuo Chao *Department of Liver Surgery, Peking Union Medical College Hospital, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, China.ORCID https://orcid.org/0000-0002-6578-5967
Yuan Liang *School of Biological Science & Medical Engineering, Southeast University, Nanjing, Jiangsu, China.
Hao Wang *Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Ziyu Xun *Department of Liver Surgery, Peking Union Medical College Hospital, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, China.
Shanshan Wang *Department of Surgery, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Zhengfeng Xuan *Department of Liver Surgery, Peking Union Medical College Hospital, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, China.
Mingming WangDepartment of Liver Surgery, Peking Union Medical College Hospital, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, China.
Qiyuan HuangHepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Rui ZhangJiangsu Key Laboratory of Organ Transplantation and Transplant Immunology and Hepatobiliary Center, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Mu LiuHepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Lei ZhangHepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Bohang ShouDepartment of Life Science, University of California Los Angeles, Los Angeles, CA, USA.
Yuhan ZhangChina-Japan Friendship Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, China.
Feng ChengHepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. docchengfeng@njmu.edu.cn.ORCID http://orcid.org/0000-0001-6131-2970
Haitao ZhaoDepartment of Liver Surgery, Peking Union Medical College Hospital, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, China. zhaoht@pumch.cn.ORCID http://orcid.org/0000-0002-3444-8044
Ling LuJiangsu Key Laboratory of Organ Transplantation and Transplant Immunology and Hepatobiliary Center, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China. lvling@njmu.edu.cn.ORCID https://orcid.org/0000-0002-4983-5557

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin B2 (VB2) metabolism regulates numerous cellular processes, but its role in hepatocellular carcinoma (HCC) progression remains unclear. Here we show that HCC tumors are characterized by upregulation of a VB2 metabolism signature, and VB2 metabolism promotes HCC progression. Among VB2 metabolic enzymes, flavin adenine dinucleotide synthase (FADS) is the only one that is widely overexpressed in human HCC. Elevated FADS expression correlates with resistance to anti-PD-1 therapy and poor prognosis. In vivo, FADS facilitates HCC cell growth and suppresses T cell-mediated antitumor immunity. Single-cell transcriptomic analysis reveals that FADS-induced changes occur both in the tumor cells and the intra-tumoral CD8

Indexed as

Carcinoma, HepatocellularCD8-Positive T-LymphocytesFerroptosisLiver NeoplasmsAnimalsCell Line, TumorDrug Resistance, NeoplasmFemaleGene Expression Regulation, NeoplasticHumansMaleMiceRNA-Binding ProteinsRNA-Binding Proteins

Identifiers

PMID41162372
PMCPMC12572645

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.