Evidence map›Paper›PMID 41162366›Full record

ArticleNature communications2025

Upcycling waste polystyrene to adipic acid through a hybrid chemical and biological process.

Hyunjin Moon, Jason S DesVeaux, Elisabeth C Van Roijen, Christine A Singer, Hannah M Alt, Mikhail O Konev, Clarissa Lincoln, Young-Saeng C Avina, Nicolette R Meyer, Stefan J Haugen and 11 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Hyunjin Moon *Renewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO, USA.ORCID http://orcid.org/0000-0002-9780-419X
Jason S DesVeaux *BOTTLE Consortium, Golden, CO, USA.ORCID http://orcid.org/0000-0001-7926-6327
Elisabeth C Van RoijenBOTTLE Consortium, Golden, CO, USA.
Christine A SingerRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO, USA.
Hannah M AltRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO, USA.
Mikhail O KonevRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO, USA.
Clarissa LincolnRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO, USA.
Young-Saeng C AvinaRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO, USA.ORCID http://orcid.org/0000-0003-3769-4862
Nicolette R MeyerRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO, USA.
Stefan J HaugenRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO, USA.
Hyeongeon LeeSchool of Energy and Chemical Engineering, and Graduate School of Carbon Neutrality, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.ORCID http://orcid.org/0009-0003-8872-8396
Kwangjin AnSchool of Energy and Chemical Engineering, and Graduate School of Carbon Neutrality, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.ORCID http://orcid.org/0000-0002-5239-0296
Joel MiscallRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO, USA.ORCID http://orcid.org/0000-0002-4513-8703
Kelsey J RamirezRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO, USA.ORCID http://orcid.org/0000-0002-5114-742X
Christopher W JohnsonRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO, USA.ORCID http://orcid.org/0000-0002-2979-4751
Davinia SalvachúaRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO, USA.ORCID http://orcid.org/0000-0003-0799-061X
Bruno C KleinCatalytic Carbon Transformation and Scale-up Center, National Renewable Energy Laboratory, Golden, CO, USA.ORCID http://orcid.org/0000-0003-3438-253X
Taylor UekertBOTTLE Consortium, Golden, CO, USA.ORCID http://orcid.org/0000-0001-7645-9166
Allison Z WernerRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO, USA.ORCID http://orcid.org/0000-0001-7147-2863
Shannon S StahlBOTTLE Consortium, Golden, CO, USA. stahl@chem.wisc.edu.ORCID http://orcid.org/0000-0002-9000-7665
Gregg T BeckhamRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO, USA. gregg.beckham@nrel.gov.ORCID http://orcid.org/0000-0002-3480-212X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative catalytic depolymerization of polystyrene (PS) can produce benzoic acid, but the annual consumption of benzoic acid is ~40 times lower than PS. For this catalytic oxidation method to be a viable means to manage PS waste, benzoic acid should be converted to higher-volume chemicals. We demonstrate a hybrid chemical and biological process that uses PS as feedstock for production of adipic acid, a high-volume co-monomer for nylon 6,6 via benzoic acid. Mn/Br co-catalyzed autoxidation of PS to benzoic acid proceeds with a yield of up to 94% in a solvent mixture of benzoic acid and water. The PS-derived benzoic acid undergoes bioconversion at near-quantitative yield to muconic acid, which is readily converted to adipic acid through catalytic hydrogenation. Process modeling, techno-economic analysis, and life cycle assessment estimate an adipic acid minimum selling price of $3.18/kg, with a 61% decrease in greenhouse gas emissions relative to production from fossil fuels.

Identifiers

PMID41162366
PMCPMC12572117

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.