Evidence map›Paper›PMID 41162192›Full record

ArticlePhysiological reports2025

UNI-494 treatment improves measures of renal dysfunction and cardiac pathology in male rats receiving L-NAME and angiotensin II.

Fiona Jing Min Ho, Clarice Jing Rou Siow, Hayat Aljaibeji, Miao Ding, Richard N Mitchell, Satya Medicherla, Guru Reddy, Shalabh Gupta, Gordon H Williams, Jose R Romero

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fiona Jing Min HoDivision of Endocrinology, Diabetes and Metabolism, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts, USA.
Clarice Jing Rou SiowDivision of Endocrinology, Diabetes and Metabolism, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts, USA.
Hayat AljaibejiDivision of Endocrinology, Diabetes and Metabolism, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts, USA.
Miao DingDivision of Endocrinology, Diabetes and Metabolism, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts, USA.
Richard N MitchellDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Satya MedicherlaUnicycive Therapeutics Inc., Los Altos, California, USA.
Guru ReddyUnicycive Therapeutics Inc., Los Altos, California, USA.
Shalabh GuptaUnicycive Therapeutics Inc., Los Altos, California, USA.
Gordon H WilliamsDivision of Endocrinology, Diabetes and Metabolism, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts, USA.
Jose R RomeroDivision of Endocrinology, Diabetes and Metabolism, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-8225-0772

Funding

BWH | Brigham Research Institute (BRI)Unicycive Therapeutics, Inc.
6 · The paper itself

Abstract

Mitochondrial dysfunction is essential in the pathophysiology of both cardiovascular disease (CVD) and chronic kidney disease (CKD). Nicorandil, a nicotinamide nitrate derivative, has been used for years as a cardioprotective agent. It binds to sulfonylurea receptors, activating mitochondrial ATP-sensitive potassium channels (MitoK

Indexed as

Angiotensin IIKidneyNG-Nitroarginine Methyl EsterNiacinamideAnimalsMaleRatsRats, Sprague-DawleyAngiotensin IING-Nitroarginine Methyl EsterNiacinamidealbuminuriaangiotensin II (ANG II)cardiac damagecardiorenal diseaseCVD (cardiovascular disease)kidney injury molecule (KIM‐1)nicorandilN‐omega‐nitro‐L‐arginine methyl ester (L‐NAME)

Identifiers

PMID41162192
PMCPMC12571543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.