Evidence map›Paper›PMID 41162148›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

A Novel Mouse Model for Developmental and Epileptic Encephalopathy by Purkinje Cell-Specific Deletion of

Fernando Isaac Guillén, Mendee A Geist, Shao-Ying Cheng, Arwen M Harris, Martha E Treviño, Hiroshi Nishiyama, Audrey C Brumback, MacKenzie A Howard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Fernando Isaac GuillénDepartment of Neurology, Dell Medical School, University of Texas at Austin, Austin, Texas 78712.ORCID 0009-0002-3871-604X
Mendee A GeistDepartment of Neurology, Dell Medical School, University of Texas at Austin, Austin, Texas 78712.
Shao-Ying ChengDepartment of Neuroscience, University of Texas at Austin, Austin, Texas 78712.
Arwen M HarrisDepartment of Neurology, Dell Medical School, University of Texas at Austin, Austin, Texas 78712.
Martha E TreviñoDepartment of Neurology, Dell Medical School, University of Texas at Austin, Austin, Texas 78712.
Hiroshi NishiyamaDepartment of Neuroscience, University of Texas at Austin, Austin, Texas 78712.ORCID 0000-0001-5034-5777
Audrey C BrumbackDepartment of Neurology, Dell Medical School, University of Texas at Austin, Austin, Texas 78712 audrey.brumback@austin.utexas.edu mackenziehoward@austin.utexas.edu.ORCID 0000-0002-4904-4368
MacKenzie A HowardDepartment of Neurology, Dell Medical School, University of Texas at Austin, Austin, Texas 78712 audrey.brumback@austin.utexas.edu mackenziehoward@austin.utexas.edu.ORCID 0000-0003-2832-6873

Funding

Functional architecture of the mediodorsal thalamusR01MH131857 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI BRUMBACK, AUDREY CHRISTINE · 2023 to 2025
$2.3M
Mechanisms of altered synaptic integration and plasticity underlying cellular and circuit dysfunction in genetic epilepsy disordersR01NS112500 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI HOWARD, MACKENZIE A · 2020 to 2024
$1.8M
NIMH NIH HHS R01 MH131857NINDS NIH HHS R01 NS112500
6 · The paper itself

Abstract

Loss of function variants of

Indexed as

Disease Models, AnimalEpilepsyPurkinje CellsVoltage-Gated Sodium Channel beta-1 SubunitAnimalsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicScn1b protein, mouseVoltage-Gated Sodium Channel beta-1 Subunitautism spectrum disordercerebellumdevelopmental and epileptic encephalopathiesDravetelectrophysiologyepilepsy

Identifiers

PMID41162148
PMCPMC12696634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.