ReviewHandbook of clinical neurology2025
Placebo and nocebo effect in pain.
Review in Handbook of clinical neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Placebo and nocebo effects on pain through the lens of the predictive brain: Neurobiological mechanisms and translational implications.Experimental physiology · 2026Review
- Targeting neuroimmune pathways in chronic pain: clinical insights and immunotherapeutic prospects.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Understanding the mechanisms of pain modulation is pivotal for elucidating the role of the placebo effect in pain management. This chapter addresses the neurophysiological underpinnings of pain modulation induced by the placebo effect, emphasizing the mechanisms of descending pain processing and placebo-induced analgesia in chronic pain conditions. The placebo effect can modulate various dimensions of pain perception, including the nociceptive, sensory-discriminative, and the cognitive-affective dimensions. In this chapter, the focus is on the motivational-affective dimension and its significant impact on placebo responses, particularly focusing on the roles of expectations, past experiences, and social learning. Additionally, the placebo effect is influenced by individual characteristics, such as age, sex, gender, race, and sleep patterns. Highlighted are the complexity of placebo-induced pain relief and the need for further research into these interacting factors to optimize clinical outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.