Evidence map›Paper›PMID 41161832›Full record

ArticleBMJ open2025

Distal Radius Interventions for Fracture Treatment (DRIFT) trial: study protocol for a multicentre randomised clinical trial of completely translated distal radius fractures at paediatric hospitals in North America.

Lauren Balmert Bonner, Joseph Janicki, Andrew Georgiadis, Walter Truong, Dorothy Harris Beauvais, Mohan Belthur, Erika L Daley, Jeanne Franzone, Andrew Howard, Collin May and 44 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05131685 (Reduction and Nonreduction Treatment of Displaced Pediatric Distal Radius Fractures), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05131685 narecruitingnot on this map

Reduction and Nonreduction Treatment of Displaced Pediatric Distal Radius Fractures (Peds-DRIFT Trial - Distal Radius Interventions for Fracture Treatment)

TypeinterventionalSponsorAnn & Robert H Lurie Children's Hospital of ChicagoRan2023 to 2031Enrolled334ConditionsFracture Distal RadiusArmsReduction, Immobilization
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

54 authors.

Lauren Balmert BonnerBiostatistics Collaboration Center and Northwestern University Data Analysis and Coordinating Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Joseph JanickiDivision of Orthopaedics & Sports Medicine, Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Andrew GeorgiadisOrthopaedic Surgery, Gillette Children's Specialty Healthcare, Saint Paul, Minnesota, USA.
Walter TruongOrthopaedic Surgery, Gillette Children's Specialty Healthcare, Saint Paul, Minnesota, USA.
Dorothy Harris BeauvaisOrthopedics and Sports Medicine, Texas Children's Hospital, Houston, Texas, USA.
Mohan BelthurOrthopedic Surgery and Sports Medicine, Phoenix Children's Hospital, Phoenix, Arizona, USA.
Erika L DaleyPediatric Orthopedic Surgery, Riley Hospital for Children, Indianapolis, Indiana, USA.
Jeanne FranzoneDepartment of Orthopedics, Nemours Children's Hopistal, Wilmington, Delaware, USA.
Andrew HowardDivision of Orthopaedic Surgery, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Collin MayDepartment of Orthopedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA.
Frank RockholdDepartment of Biostatistics and Bioinformatics, Duke University Medical Center and Duke Clinical Research Institute, Durham, North Carolina, USA.ORCID http://orcid.org/0000-0003-3732-4765
Jacob SchulzDivision of Pediatric Orthopedic Surgery, Montefiore- Einstein, Bronx, New York, USA.
Mary BaileyDuke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.
Karen ChiswellDuke Clinical Research Institute, Durham, North Carolina, USA.
Jesse DeLaRosaDuke Clinical Research Institute, Durham, North Carolina, USA.
Jaysson T BrooksDepartment of Orthopaedics, Texas Scottish Rite Hospital for Children, Dallas, Texas, USA.
Anthony A CantanzanoDuke University School of Medicine, Durham, North Carolina, USA.
Andrea ChanOrthopaedics, The Hospital for Sick Children, Toronto, Ontario, Canada.
Alice ChuPediatric Orthopaedic Surgery, Rutgers Health, Newark, New Jersey, USA.
Emily R DodwellPediatric Orthopaedics, Hospital for Special Surgery, New York City, New York, USA.
Ron El-HawaryDalhousie University, Halifax, Nova Scotia, Canada.
Henry EllisDepartment of Orthopaedic Surgery, Texas Scottish Rite Hospital for Children, Dallas, Texas, USA.
Ryan FitzgeraldChildren's Orthopedic and Scoliosis, Johns Hopkins All Children's Hospital, Tampa, Florida, USA.
Steven FrickStanford Medicine Children's Health 900 Welch Road, Palo Alto, California, USA.
Theodore J GanleyDivision of Orthopaedics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Dominic GargiuloOrthopaedic Surgery, Children's Hospital New Orleans, New Orleans, Louisiana, USA.
Luke GauthierOrthopaedic Surgery, IWK Health Centre, Halifax, Nova Scotia, Canada.
Corey S GillDepartment of Orthopaedics, Texas Scottish Rite Hospital for Children, Dallas, Texas, USA.
Rachel GoldsteinChildren's Orthopaedic Center, Children's Hospital Los Angeles, Los Angeles, California, USA.
Matthew F HalseyDepartment of Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, Oregon, USA.
Christina HardestyPediatric Orthopaedic Surgery, University Hospitals Rainbow Babies & Children's Hospital, Cleveland, Ohio, USA.
Christine HoOrthopaedic Surgery, Scottish Rite for Children, Dallas, Texas, USA.
Neil KaushalPediatric Orthopaedic Surgery, Rutgers Health, Newark, New Jersey, USA.
John Todd LawrenceDivision of Orthopaedics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
R Jay LeePediatric Orthopaedics, Johns Hopkins Medicine, Baltimore, Maryland, USA.
Khristinn K LeitchOrthopaedic Surgery and Rehabilitation, The University of Mississippi Medical Center, Jackson, Mississippi, USA.
Karim MasrouhaOrthopedic Surgery, New York University School of Medicine, New York City, New York, USA.
Stuart MitchellOrthopaedics, The University of North Carolina at Chapel Hill Department of Medicine, Chapel Hill, North Carolina, USA.
Natasha OMalleyOrthopaedics and Physical Performance, Pediatrics, University of Rochester Medical Center, Rochester, New York, USA.
Monica Payares-LizanoOrthopedic Surgery, Nicklaus Children's Hospital, Miami, Florida, USA.
Daniel PerryUniversity of Liverpool, Liverpool, UK.
Wendy RamalingamOrthopaedic Surgery, Cincinnati Children's, Cincinnati, Ohio, USA.
Jason RhodesOrthopaedic Surgery, Children's Hospital Colorado, Aurora, Colorado, USA.
Julia SandersOrthopaedic Surgery, Children's Hospital Colorado, Aurora, Colorado, USA.
Apurva S ShahOrthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Melinda SharkeyOrthopaedic Surgery, Montefiore Health System, Bronx, New York, USA.
Mauricio SilvaOrthopaedic Institute for Children, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA.
Selina SilvaOrthopaedics and Rehabilitation, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Rachael ThompsonOrthopaedic Institute for Children, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA.
John VorhiesPediatric Orthopedic Surgery, Stanford Medicine Children's Health 900 Welch Road, Palo Alto, California, USA.
James Gardner WrightOrthopaedics, The Hospital for Sick Children, Toronto, Ontario, Canada.
Candace YoungDivision of Orthopaedics & Sports Medicine, Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA cayoung@luriechildrens.org.ORCID http://orcid.org/0000-0002-2491-6289
Jamie BurgessDivision of Orthopaedics & Sports Medicine, Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
IMPACCT Consortium

Funding

IMPACCT: Infrastructure for Musculoskeletal Pediatric Acute Care Clinical TrialsU01AR079113 · NIAMS · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI Joseph A Janicki · 2021 to 2026
$6.7M
IMPACCT – Infrastructure for Musculoskeletal Pediatric Acute Care Clinical TrialsR34AR075303 · NIAMS · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI JANICKI, JOSEPH A · 2019 to 2020
$478k
NIAMS NIH HHS R34 AR075303NIAMS NIH HHS U01 AR079113
6 · The paper itself

Abstract

introductionDistal radius fractures are the most common fractures seen in the emergency department in children in the USA. However, no established or standardised guidelines exist for the optimal management of completely displaced fractures in younger children. The proposed multicentre randomised trial will compare functional outcomes between children treated with fracture reduction under sedation versus children treated with simple immobilisation. METHODS AND ANALYSIS: Participants aged 4-10 years presenting to the emergency department with 100% dorsally translated metaphyseal fractures of the radius less than 5 cm from the distal radial physis will be recruited for the study. Those patients with open fractures, other ipsilateral arm fractures (excluding ulna), pathologic fractures, bone diseases, or neuromuscular or metabolic conditions will be excluded. Participants who agree to enrol in the trial will be randomly assigned via a minimal sufficient balance algorithm to either sedated reduction or in situ immobilisation. A sample size of 167 participants per arm will provide at least 90% power to detect a difference in the primary outcome of Patient-Reported Outcomes Measurement Information System Upper Extremity computer adaptive test scores of 4 points at 1 year from treatment. Primary analyses will employ a linear mixed model to estimate the treatment effect at 1 year. Secondary outcomes include additional measures of perceived pain, complications, radiographic angulation, satisfaction and additional procedures (revisions, refractures, reductions and reoperations). ETHICS AND DISSEMINATION: Ethical approval was obtained from the following local Institutional Review Boards: Advarra, serving as the single Institutional Review Board, approved the study (Pro00062090) in April 2022. The Hospital for Sick Children (Toronto, ON, Canada) did not rely on Advarra and received separate approval from their local Research Ethics Board (REB; REB number: 1000079992) on 19 July 2023. Results will be disseminated through publication in peer-reviewed journals and presentations at international conference meetings. TRIAL REGISTRATION NUMBER: NCT05131685.

Indexed as

Fracture FixationImmobilizationRadius FracturesChildChild, PreschoolEmergency Service, HospitalFemaleHospitals, PediatricHumansMaleMulticenter Studies as TopicNorth AmericaRandomized Controlled Trials as TopicWrist FracturesClinical TrialORTHOPAEDIC & TRAUMA SURGERYPaediatric orthopaedicsRandomized Controlled Trial

Identifiers

PMID41161832
PMCPMC12574372

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.