Evidence map›Paper›PMID 41161782›Full record

ArticleJournal of clinical and experimental hematopathology : JCEH2025

Mixed-phenotype acute leukemia with trilineage differentiation presenting as a non-leukemic mediastinal tumor.

Satoshi Ichikawa, Maya Yamato, Shusuke Hatta, Koichi Onodera, Noriko Fukuhara, Ryo Ichinohasama, Hideo Harigae

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental hematopathology : JCEH, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Satoshi IchikawaDepartment of Hematology, Tohoku University Hospital, Sendai, Japan.
Maya YamatoDepartment of Hematology, Tohoku University Hospital, Sendai, Japan.
Shusuke HattaDepartment of Hematology, Tohoku University Hospital, Sendai, Japan.
Koichi OnoderaDepartment of Hematology, Tohoku University Hospital, Sendai, Japan.
Noriko FukuharaDepartment of Hematology, Tohoku University Hospital, Sendai, Japan.
Ryo IchinohasamaDepartment of Hematopathology, Tohoku University Hospital, Sendai, Japan.
Hideo HarigaeDepartment of Hematology, Tohoku University Hospital, Sendai, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mixed-phenotype acute leukemia (MPAL) is an uncommon hematological malignancy, and cases exhibiting trilineage differentiation are extraordinarily rare. Here, we report the case of a 63-year-old male patient who presented with severe dyspnea secondary to a massive anterior mediastinal mass and pleural effusion, in the absence of detectable abnormal cells in the peripheral blood. Immunophenotypic analysis of pleural fluid and tumor biopsy revealed an unprecedented trilineage phenotype with concurrent expression of T-lymphoid (cytoplasmic CD3

Indexed as

Leukemia, Biphenotypic, AcuteMediastinal NeoplasmsHumansImmunophenotypingMaleMiddle Agedallogeneic hematopoietic stem cell transplantationearly T-cell precursor acute lymphoblastic leukemiamixed-phenotype acute leukemiaT-cell lymphoblastic lymphomatrilineage phenotype

Identifiers

PMID41161782
PMCPMC12883020

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.