Evidence map›Paper›PMID 41161780›Full record

ReviewJournal of clinical and experimental hematopathology : JCEH2025

Solitary plasmacytoma of maxilla with Epstein Barr virus: A case report and literature review.

Chiho Hiraga, Saki Ishikawa, Takayoshi Kikuchi, Taiki Suzuki, Kazuhiko Hashimoto, Keisuke Tanaka, Kimihiro Matsumoto, Takeshi Nomura

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical and experimental hematopathology : JCEH, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chiho HiragaDepartment of Oral Oncology, Oral and Maxillofacial surgery, Tokyo Dental College, Chiba, Japan.
Saki IshikawaDepartment of Oral Oncology, Oral and Maxillofacial surgery, Tokyo Dental College, Chiba, Japan.
Takayoshi KikuchiOral Cancer Center, Tokyo Dental College, Chiba, Japan.
Taiki SuzukiDepartment of Oral and Maxillofacial surgery, Kanto Rosai Hospital, Kanagawa, Japan.
Kazuhiko HashimotoDivision of Surgical Pathology, Ichikawa General Hospital, Tokyo Dental College, Chiba, Japan.
Keisuke TanakaDepartment of Internal Medicine, Ichikawa General Hospital, Tokyo Dental College, Chiba, Japan.
Kimihiro MatsumotoDepartment of Internal Medicine, Ichikawa General Hospital, Tokyo Dental College, Chiba, Japan.
Takeshi NomuraDepartment of Oral Oncology, Oral and Maxillofacial surgery, Tokyo Dental College, Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Solitary plasmacytoma (SP) of the bone is a localized neoplasm of plasma cells that can involve the jaw. Epstein-Barr virus (EBV)-positive SP has been documented in immunocompetent individuals; however, its clinicopathological features and prognostic implications remain to be fully clarified. We report a case of EBV-positive SP of the maxilla in a 74-year-old partially edentulous man who presented with swelling in the left posterior maxilla. The lesion measured approximately 30 mm and was covered by intact mucosa. Histopathological examination and systemic evaluation confirmed EBV-positive SP localized to the maxilla. The patient initially received radiotherapy without effect. Subsequently, chemotherapy with ixazomib, lenalidomide, and dexamethasone was administered, resulting in a complete response. No local recurrence was observed after 2 years and 6 months of follow-up. This case highlights the potential for chemotherapy in managing radiotherapy-resistant EBV-positive SP. Further studies are warranted to better understand the pathogenesis and treatment strategies for this rare condition.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsEpstein-Barr Virus InfectionsMaxillary NeoplasmsPlasmacytomaAgedBiopsyBoron CompoundsChemotherapy, AdjuvantDexamethasoneGlycineHerpesvirus 4, HumanHumansLenalidomideMaleMaxillaRNA, ViralBoron CompoundsDexamethasoneEpstein-Barr virus encoded RNA 1GlycineixazomibLenalidomideRNA, ViralEBER1-ISHEpstein-Barr virussolitary plasmacytoma

Identifiers

PMID41161780
PMCPMC12883025

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.