Evidence map›Paper›PMID 41161769›Full record

Trial reportPsycho-oncology2025

The Emotion and Symptom-Focused Engagement (EASE) Psychotherapeutic Intervention for Parents of Children With Acute Leukemia: A Feasibility Trial.

Lindsay A Jibb, Ally Yu, Stephanie Nanos, Carmine Malfitano, Laura Foran, Kate Hunt, Argin Malakian, Camilla Zimmermann, Katharina Schultebraucks, Nhu-An Pham and 3 more

Registry-linked trialAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psycho-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05236296 (Pilot Study of a Novel Psychotherapeutic Intervention for Caregivers of Patients With Acute Leukemia), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05236296 nacompletednot on this map

Pilot Study of a Novel Psychotherapeutic Intervention for Caregivers of Patients With Acute Leukemia: Emotion and Symptom-focused Engagement for Caregivers (EASE-CG)

TypeinterventionalSponsorUniversity Health Network, TorontoRan2022 to 2024Enrolled40ConditionsLeukemia, AcuteArmsEASE-CG
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lindsay A JibbHospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-6995-2825
Ally YuHospital for Sick Children, Toronto, Ontario, Canada.
Stephanie NanosHospital for Sick Children, Toronto, Ontario, Canada.
Carmine MalfitanoUniversity of Toronto, Toronto, Ontario, Canada.
Laura ForanHospital for Sick Children, Toronto, Ontario, Canada.
Kate HuntHospital for Sick Children, Toronto, Ontario, Canada.
Argin MalakianHospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0003-1322-1294
Camilla ZimmermannUniversity of Toronto, Toronto, Ontario, Canada.
Katharina SchultebraucksNew York University, New York, New York, USA.
Nhu-An PhamPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Anne RydallPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Sarah AlexanderHospital for Sick Children, Toronto, Ontario, Canada.
Gary RodinUniversity of Toronto, Toronto, Ontario, Canada.

Funding

CIHR CIHR-PJT-173255Hospital for Sick Children Garron Family Cancer Center Pitlblado Discovery Grant
6 · The paper itself

Abstract

backgroundParents of children newly diagnosed with acute leukemia (AL) experience significant traumatic stress that adversely affects their well-being, caregiving capacity, and family functioning. However, rigorous evidence of the feasibility and effectiveness of psychosocial interventions for this group remains limited.

aimsTo evaluate the study feasibility and acceptability of Emotion And Symptom-focused Engagement (EASE), a brief, manualized psychotherapeutic intervention designed to mitigate traumatic stress symptoms in individuals facing a life-threatening illness or in their close family member.

methodsThis single-arm, pre-post feasibility study recruited parents of children with AL who participated in EASE sessions delivered by trained clinicians. Measures of traumatic stress, depressive symptoms, and other psychosocial outcomes were obtained at baseline, 3- and 6-months. Feasibility was assessed based on enrollment, attrition, adherence to EASE, and questionnaire completion rates, with predefined criteria guiding trial progression. Acceptability was evaluated via thematic analysis of qualitative interviews. Descriptive statistics summarized outcome data.

resultsOf 59 parents approached, 40 (68%) enrolled. The study attrition rate was 15%. Participants attended six EASE sessions on average, with 88% receiving the minimum dose of three sessions. Outcome measures were completed by ≥ 78% of participants at each timepoint. Qualitative findings showed that EASE was well-received and provided emotional relief and enhanced coping to parents. Virtual intervention delivery and flexible scheduling facilitated engagement.

conclusionEASE is a feasible and acceptable intervention for parents of children with newly diagnosed AL, addressing critical caregiver support needs. Randomized controlled trials are warranted to evaluate its efficacy in reducing traumatic stress and improving caregiver well-being.

trial registrationNCT05236296 ClinicalTrials.gov.

Indexed as

CaregiversEmotionsLeukemiaParentsPrecursor Cell Lymphoblastic Leukemia-LymphomaPsychosocial InterventionPsychotherapyStress, PsychologicalAdaptation, PsychologicalAdolescentAdultChildChild, PreschoolDepressionFeasibility StudiesFemaleadaptationcaregiverschildemotionsfeasibility Studieshealth careleukemiaoutcome assessmentparentspsychologicalpsychosocial interventionquestionnairessurveys

Identifiers

PMID41161769
PMCPMC12571586

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.