Evidence map›Paper›PMID 41161078›Full record

ArticleEnvironment international2025

Prenatal exposure to environmental phenolic compounds and their association with childhood atopic dermatitis, asthma, and allergic rhinitis in the ECHO cohort.

Rachel L Miller, Yuyan Wang, Jenny Aalborg, Akram N Alshawabkeh, Joseph M Braun, Carrie V Breton, Courtney C Carignan, Dana Dabelea, Anne L Dunlop, Assiamira Ferrara and 23 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Rachel L MillerDivision of Clinical Immunology, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Pl, New York, NY 10029, USA. Electronic address: rachel.miller2@mssm.edu.
Yuyan WangNYU Grossman School of Medicine, 180 Madison Ave, New York, NY 10016, USA. Electronic address: Yuyan.Wang@nyulangone.org.
Jenny AalborgUniversity of Colorado Anschutz Medical Campus, 1890 North Revere Court, 1013, Aurora, CO 80045, USA. Electronic address: jenny.aalborg@cuanschutz.edu.
Akram N AlshawabkehCollege of Civil and Environmental Engineering, Northeastern University, 555 ISEC Building, 360 Huntington Ave, Boston, MA 02115, USA. Electronic address: a.alshawabkeh@northeastern.edu.
Joseph M BraunDepartment of Epidemiology, Brown University, Box G-S121(2), Providence RI 02912, USA. Electronic address: joseph_braun_1@brown.edu.
Carrie V BretonDepartment of Population and Public Health Sciences, University of Southern California, 1845 N Soto St., Los Angeles CA 90032, USA. Electronic address: breton@usc.edu.
Courtney C CarignanDepartment of Food Science and Human Nutrition, Department of Pharmacology and Toxicology, Michigan State University, G.M. Trout Food Science Building, 469 Wilson Road, East Lansing, MI 48824, USA. Electronic address: carigna4@msu.edu.
Dana DabeleaLEAD Center, University of Colorado School of Medicine, University of Colorado Anschutz Medical Campus, Campus Box F426, AHSB, 1890 N. Revere Ct., Aurora, CO 80045-7464, USA. Electronic address: dana.dabelea@cuanschutz.edu.
Anne L DunlopDepartment of Gynecology & Obstetrics, Emory University School of Medicine, 101 Woodruff Circle, Rm 4313 Woodruff Memorial Building Atlanta, GA 30322, USA. Electronic address: amlang@emory.edu.
Assiamira FerraraKaiser Permanente Northern California Division of Research, 4480 Hacienda Drive, Pleasanton, CA 94588-2761, USA. Electronic address: Assiamira.Ferrara@kp.org.
Griffith GaoNortheastern University, Department of Civil and Environmental Engineering, 360 Huntington Ave, Boston, MA, USA. Electronic address: q.gao@northeastern.edu.
Abigail GaylordDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, 722 W 168th St, New York, NY 10032, USA. Electronic address: alg2215@cumc.columbia.edu.
Sarah D GeigerDepartment of Health and Kinesiology, University of Illinois, The Beckman Institute for Advanced Science and Technology, 405 N Mathews Ave, Urbana IL 61801, USA. Electronic address: smurphy7@illinois.edu.
Diane R GoldDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, 655 Huntington Ave, Boston MA 02115, USA; Channing Division of Network Medicine, Harvard Medical School, Department of Medicine, Brigham and Women's Hospital, 181 Longwood, Boston MA 02115, USA. Electronic address: redrg@channing.harvard.edu.
Mehtap Haktanir AbulBrown University Health, 593 Eddy Street, Providence, RI 02903, USA. Electronic address: mehtap_haktanir_abul@brown.edu.
Tina V HartertDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, 2525 West End Ave, Suite 450, Vanderbilt University School of Medicine, Nashville, TN 37203, USA. Electronic address: tina.hartert@vumc.org.
Julie HerbstmanDepartment of Environmental Health Sciences, Columbia Mailman School of Public Health, 722 W168th Street, New York, NY 10032, USA. Electronic address: jh2678@cumc.columbia.edu.
Lori A HoepnerSUNY Downstate Health Sciences University, Department of Environmental and Occupational Health Sciences, 445 Lenox Road, Brooklyn, NY 11203, USA. Electronic address: Lori.Hoepner@downstate.edu.
Margaret R KaragasDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, 1 Medical Center Drive, Williamson Translational Research Building, 7th Floor, Lebanon, NH 03756, USA. Electronic address: margaret.r.karagas@dartmouth.edu.
Catherine J KarrUniversity of Washington, Departments of Pediatrics & Environmental & Occupational Health Sciences, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA. Electronic address: ckarr@uw.edu.
Rachel S KellyChanning Division of Network Medicine, Harvard Medical School, Department of Medicine, Brigham and Women's Hospital, 181 Longwood, Boston MA 02115, USA.
Camilo E KhatchikianDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, 1 Medical Center Drive, Williamson Translational Research Building, 7th Floor, Lebanon, NH 03756, USA. Electronic address: camilo.Khatchikian@dartmouth.edu.
Mengling LiuNYU Grossman School of Medicine, Department of Population Health 180 Madison Ave, New York, NY 10016, USA. Electronic address: Mengling.Liu@nyulangone.org.
Kristen LyallDepartment of Epidemiology and Biostatistics, Drexel University, 3215 Market St Philadelphia PA 19104, USA. Electronic address: kld98@drexel.edu.
John D MeekerDepartment of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109-2029, USA. Electronic address: meekerj@umich.edu.
Rachel Morello-FroschSchool of Public Health and Department of Environmental Science, Policy and Management, University of California, 130 Mulford Hall, Berkeley, CA 94720-3114, USA. Electronic address: rmf@berkeley.edu.
Thomas G O'ConnorDepartments of Psychiatry, Neuroscience, Obstetrics and Gynecology, University of Rochester, 300 Crittenden Blvd, Rochester, NY 14642 USA. Electronic address: tom_oconnor@urmc.rochester.edu.
Jiwon OhDepartment of Public Health Sciences, University of California Davis Medical Sciences 1-C, 1 Shields Avenue, Davis, CA 95616, USA. Electronic address: jiwoh@ucdavis.edu.
Sheela SathyanarayanaDepartment of Pediatrics, Department of Environmental and Occupational Health Sciences, University of Washington, Center for Health, Behavior and Development, Seattle Children's Research Institute, 4800 Sand Point Way NE, Seattle, WA 98105, USA. Electronic address: sheela.sathyanarayana@seattlechildrens.org.
Joanne E SordilloDepartment of Population Medicine, Harvard Pilgrim Healthcare Institute, Harvard Medical School, 401 Park Drive, Suite 401 East, Boston, MA 02215, USA. Electronic address: joanne.e.sordillo@gmail.com.
Leonardo TrasandeNYU Grossman School of Medicine Department of Pediatrics, 227 E 30th St Rm 615, New York NY 10016, USA. Electronic address: Leonardo.Trasande@nyulangone.org.
Tracey J WoodruffProgram on Reproductive Health & the Environment, University of California San Francisco, Box: 0132, Bldg: 550 16th Street, Room: 7330, San Francisco, CA 94158, USA. Electronic address: Tracey.Woodruff@ucsf.edu.
ECHO Cohort Consortium

Funding

Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI Phillip Brian Smith · 2016 to 2026
$215.9M
ECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)U24OD023382 · OD · JOHNS HOPKINS UNIVERSITY · PI Diane J Catellier, LISA P JACOBSON · 2016 to 2026
$148.4M
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-UpUH3OD023282 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern · 2018 to 2026
$64.8M
The NYU Children’s Health & Environment Study: an ECHO CohortUH3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Akhgar Ghassabian, Leonardo Trasande · 2018 to 2026
$59.5M
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
The ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child HealthU24OD023319 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Courtney K Blackwell, RICHARD GERSHON · 2016 to 2026
$43.7M
Research Experiences and Training Coordination CoreP42ES017198 · NIEHS · NORTHEASTERN UNIVERSITY · PI PIEPER, KELSEY JANETTE · 2010 to 2024
$38.6M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
Viral and Host Determinants of Infant and Childhood Allergy and AsthmaU19AI095227 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Dawn C Newcomb · 2011 to 2026
$34.9M
NCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1 TR002243NCATS NIH HHS UL1 TR004419NHLBI NIH HHS K01 HL146980NHLBI NIH HHS T32 HL007343NIAID NIH HHS U19 AI095227NIAID NIH HHS U24 AI179612NIEHS NIH HHS P01 ES022841NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P42 ES017198NIEHS NIH HHS R01 ES032808NIEHS NIH HHS U24 ES026539NIEHS NIH HHS U2C ES026533NIEHS NIH HHS U2C ES026542NIEHS NIH HHS U2C ES026555NIEHS NIH HHS U2C ES026561NIEHS NIH HHS U2C ES030851NIEHS NIH HHS U2C ES030857NIEHS NIH HHS U2C ES030859NIH HHS U24 OD023319NIH HHS U24 OD023382NIH HHS U24 OD035523NIH HHS U2C OD023375NIH HHS UG3 OD023290NIH HHS UG3 OD035508NIH HHS UG3 OD035509NIH HHS UG3 OD035513NIH HHS UG3 OD035516NIH HHS UG3 OD035517NIH HHS UG3 OD035518NIH HHS UG3 OD035519NIH HHS UG3 OD035521NIH HHS UG3 OD035526NIH HHS UG3 OD035527NIH HHS UG3 OD035528NIH HHS UG3 OD035529NIH HHS UG3 OD035532NIH HHS UG3 OD035533NIH HHS UG3 OD035536NIH HHS UG3 OD035537NIH HHS UG3 OD035540NIH HHS UG3 OD035542NIH HHS UG3 OD035543NIH HHS UG3 OD035544NIH HHS UG3 OD035546NIH HHS UG3 OD035550NIH HHS UH3 OD023244NIH HHS UH3 OD023248NIH HHS UH3 OD023249NIH HHS UH3 OD023251NIH HHS UH3 OD023253NIH HHS UH3 OD023268NIH HHS UH3 OD023271NIH HHS UH3 OD023279NIH HHS UH3 OD023282NIH HHS UH3 OD023286NIH HHS UH3 OD023287NIH HHS UH3 OD023289NIH HHS UH3 OD023290NIH HHS UH3 OD023305NIH HHS UH3 OD023313NIH HHS UH3 OD023318NIH HHS UH3 OD023320NIH HHS UH3 OD023328NIH HHS UH3 OD023332NIH HHS UH3 OD023344NIH HHS UH3 OD023347NIH HHS UH3 OD023348NIH HHS UH3 OD023349NIH HHS UH3 OD023389NIH HHS UH3 OD035509NIH HHS UH3 OD035516NIH HHS UH3 OD035518NIH HHS UH3 OD035519NIH HHS UH3 OD035521NIH HHS UH3 OD035528NIH HHS UH3 OD035529NIH HHS UH3 OD035533NIH HHS UH3 OD035542NIH HHS UH3 OD035543NIH HHS UH3 OD035546NIH HHS UH3 OD035550
6 · The paper itself

Abstract

Phenolic compounds may be harmful to the developing fetus, but many have not been studied in-depth for adverse childhood allergic and respiratory health effects. We hypothesized that higher levels of phenolic compounds in prenatal spot urine would be associated with greater odds of childhood atopic dermatitis, allergic rhinitis, and asthma, and that child sex may modify these associations. 3198 mother-child paired cases were enrolled from 16 cohorts in the U.S. ECHO consortium. Fifteen phenols (e.g. benzophenones, parabens, bisphenols, triclosans) were measured from mother's urine during pregnancy using a multi-class chemical panel. Childhood outcomes included parent-reported atopic dermatitis (1466 mother-child pairs) between ages 0-3 years, and allergic rhinitis (901 mother-child pairs) and asthma (1662 mother-child pairs) between ages 5-9 years. Prenatal parabens were associated with increased odds of atopic dermatitis (odds ratio (OR) 1.13, 95 % confidence intervals (CI) 1.02, 1.26). Benzophenones were associated with lower odds of asthma (OR 0.77, CI 0.66, 0.90). Compared to boys, girls demonstrated higher odds of parabens (1.21, CI 1.04, 1.42), benzophenones (1.18, CI 1.00, 1.38) and bisphenol S (1.21, CI 1.03, 1.43) being associated with atopic dermatitis, and of the benzophenones (1.46, CI 1.11, 1.93) being associated with allergic rhinitis. An association of benzophenones (0.66, CI 0.53, 0.83) with lower odds of asthma was stronger among boys. These findings suggest that prenatal paraben and other phenol exposures may adversely affect early-life allergic and respiratory outcomes, with sex-specific vulnerability. Novel, multi-modality approaches to reduce maternal phenol exposure during pregnancy are urgently needed to protect children's health.

Indexed as

AsthmaDermatitis, AtopicEnvironmental PollutantsMaternal ExposurePhenolsPrenatal Exposure Delayed EffectsRhinitis, AllergicAdultChildChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornMaleEnvironmental PollutantsParabensPhenolsBisphenolsChildhood allergyChildhood asthmaParabensPhenolsPrenatal exposureTriclosan

Identifiers

PMID41161078
PMCPMC12767510

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