Evidence map›Paper›PMID 41160984›Full record

ArticleJournal of biophotonics2026

Assessing Effects of Riboflavin/UV-A Cross-Linking on Aqueous Outflow Facility, Corneal Biomechanics and Their Association With Intraocular Pressure.

Yilong Zhang, Zhengshuyi Feng, Xingyu Jiang, Robert Scott, Ying Yang, Chunhui Li, Zhihong Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biophotonics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yilong ZhangSchool of Physics, Engineering and Technology, University of York, York, UK.
Zhengshuyi FengSchool of Physics, Engineering and Technology, University of York, York, UK.
Xingyu JiangCentre for Medical Engineering and Technology, School of Science and Engineering, University of Dundee, Dundee, UK.
Robert ScottThéa Pharmaceuticals Ltd, Keele, UK.
Ying YangSchool of Pharmacy and Bioengineering, Keele University, Stoke-on-Trent, UK.
Chunhui LiCentre for Medical Engineering and Technology, School of Science and Engineering, University of Dundee, Dundee, UK.ORCID 0000-0003-2186-5137
Zhihong HuangSchool of Physics, Engineering and Technology, University of York, York, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Riboflavin/UV-A corneal collagen cross-linking (CXL) is a standard treatment for early-stage keratoconus. However, quantitative CXL outcomes remain limited. This study evaluated CXL effects on outflow facility and corneal biomechanics at intraocular pressures (IOPs) in ex vivo porcine eyes. Ocular rigidity and outflow facility were derived from pressure-volume and IOP decay curves using a direct manometric technique, while corneal elasticity (Young's modulus) was measured via non-contact air-pulse optical coherence elastography. CXL increased ocular rigidity (0.0066 ± 0.0001 μL

Indexed as

Aqueous HumorCorneaCross-Linking ReagentsIntraocular PressureRiboflavinUltraviolet RaysAnimalsBiomechanical PhenomenaCollagenSwineCollagenCross-Linking ReagentsRiboflavinair‐pulse optical coherence elastographybiomechanical propertiesintraocular pressurekeratoconusmanometric measurementoutflow facilityriboflavin/UV‐A corneal collagen cross‐linking

Identifiers

PMID41160984
PMCPMC12872341

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.