ArticleNucleic acids research2026
TTDB: a comprehensive Transcriptome Turnover Database for exploring mRNA stability.
Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- 5-Azacytidine incorporation into mRNAs disrupts translation and induces ribosome collisions.bioRxiv : the preprint server for biology · 2026Article
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The regulation of messenger mRNA turnover is a critical cellular process that dictates gene expression levels. High-throughput sequencing technologies have enabled the measurement of mRNA decay rates on a transcriptome-wide scale. However, this vast amount of data is dispersed across numerous publications, and it is cumbersome to harmonize and compare. To address this, we have developed the Transcriptome Turnover Database (TTDB), a centralized and comprehensive resource for genome-wide mRNA stability data. TTDB integrates 198 high-throughput datasets from 57 publications, with an average 12 544 genes per dataset, across five species: human, mouse, zebrafish, fruit fly, and yeast. The database not only provides experimentally determined and computationally standardized mRNA half-lives and decay rates, but also offers precomputed annotations for each transcript, including GC content, minimum free energy of mRNA secondary structure, and counts of regulatory elements like upstream AUGs and AU-rich elements. The user-friendly web interface allows users to intuitively browse, search, visualize, and download data by study, sample, or gene. TTDB is publicly accessible at https://sysbio.gzzoc.com/ttdb/index.html.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.