ArticleNucleic acids research2026
MGTbind: a comprehensive database of molecular glue ternary interactome.
Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Zinc finger proteins (ZFPs) in health and disease.Molecular biomedicine · 2026Review
- A Novel Paradigm for Targeting Challenging Targets: Advancing Technologies and Future Directions of Molecular Glue Degraders.Molecules (Basel, Switzerland) · 2026Review
- The 2026 Nucleic Acids Research database issue and the online molecular biology database collection.Nucleic acids research · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Molecular glues (MGs) are an emerging class of small molecules capable of inducing or enhancing protein-protein interactions, leading to reprograming of cellular events. In recent years, MG discovery has gained significant attention in drug discovery and synthetic biology studies. However, MG discovery remains exceptionally challenging as it continues to rely on serendipity and experimental screening efforts. In order to contribute data resources to facilitate the rational design of MGs, we developed the molecular glue and ternary binding (MGTbind) database, providing comprehensive resources about ternary structures and experimental data for the coverage of MG-engaged interactome. MGTbind database contains 3093 manually curated MGs with their chemical structures and physicochemical properties, along with 3924 ternary interactions with bioactivity measurements (e.g. degradation capacities for MG degraders, in vitro biochemical activities and cellular activities). Hierarchical binding affinity is also collected to enable exploring of cooperative binding mechanisms. Ternary complex structural data are systematically integrated, either from the Protein Data Bank or generated by AlphaFold 3. All of them can be intuitively analyzed and visualized along with various predicted metrics. A fully functional and user-friendly web interface that allows global search and smooth browsing is provided and is freely accessible at https://mgtbind.pkumdl.cn.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.