Evidence map›Paper›PMID 41160880›Full record

ArticleNucleic acids research2026

DeepSpaceDB: a spatial transcriptomics atlas for interactive in-depth analysis of tissues and tissue microenvironments.

Vladyslav Honcharuk, Afeefa Zainab, Yoshiya Horimoto, Keiko Takemoto, Diego Diez, Shinpei Kawaoka, Alexis Vandenbon

Abstract read
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vladyslav HoncharukLaboratory of Tissue Homeostasis, Institute for Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Afeefa ZainabLaboratory of Tissue Homeostasis, Institute for Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Yoshiya HorimotoDepartment of Breast Surgery and Oncology, Tokyo Medical University Hospital, Tokyo 160-0023, Japan.ORCID 0000-0001-8935-0768
Keiko TakemotoLaboratory of Tissue Homeostasis, Institute for Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Diego DiezImmunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.ORCID 0000-0002-2325-4893
Shinpei KawaokaDepartment of Integrative Bioanalytics, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai 980-8575, Japan.
Alexis VandenbonLaboratory of Tissue Homeostasis, Institute for Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.ORCID 0000-0003-2180-5732

Funding

Institute for Life and Medical Sciences of Kyoto UniversityJapan Agency for Medical Research and Development JP24gm2010003Japan Science and Technology AgencyNational Bioscience Database Center JPMJND2303
6 · The paper itself

Abstract

Spatial transcriptomics enables detailed mapping of gene expression within tissues, revealing spatial organization of cellular and molecular processes. However, generating such data is costly and technically challenging, and analysis requires advanced bioinformatics skills. Although public datasets are growing, existing databases offer limited tools for interactive exploration and cross-sample comparison. Here, we introduce DeepSpaceDB (www.deepspacedb.com), a next-generation spatial transcriptomics database designed to address these challenges. The current version of DeepSpaceDB focuses on 10X Genomics Visium samples, ensuring higher-quality analyses and enhanced tools. This distinguishes it from databases that prioritize broad platform coverage over functionality. Emphasizing interactivity and advanced analytics, DeepSpaceDB enables flexible exploration of spatial transcriptomics data. Users can interactively compare gene expression across regions within or between tissue slices, such as between hippocampal areas of an Alzheimer's model mouse and a control. The database also offers quality indicators, database-wide trends, and interactive visualizations like zoomable plots and hover-based info. Moreover, these functions are not restricted to samples in our database but can also be applied to samples uploaded by users. Combining advanced tools with interactive features, DeepSpaceDB is a powerful resource for spatial transcriptomics, enabling deeper insights into tissue organization and disease biology.

Indexed as

Cellular MicroenvironmentDatabases, GeneticSpatial TranscriptomicsAlzheimer DiseaseAnimalsBreast NeoplasmsComputational BiologyData CurationDatasets as TopicDisease Models, AnimalFemaleHippocampusHumansMaleMice

Identifiers

PMID41160880
PMCPMC12807613

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.