Evidence map›Paper›PMID 41160820›Full record

Trial reportThe New England journal of medicine2025

A Randomized Trial of Physical Therapy for Meniscal Tear and Knee Pain.

Jeffrey N Katz, Jamie E Collins, Leslie Bisson, Morgan H Jones, James J Irrgang, Faith Selzer, Clare E Safran-Norton, Kurt P Spindler, Heidi Y Yang, Swastina Shrestha and 22 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter StudyComparative Study
In one paragraph

Trial report in The New England journal of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03059004 (Treatment of Meniscal Problems in Osteoarthritis), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03059004 nacompletednot on this map

Treatment of Meniscal Problems in Osteoarthritis

TypeinterventionalSponsorBrigham and Women's HospitalRan2018 to 2024Enrolled879ConditionsMeniscal Degeneration, Osteoarthritis, KneeArmsTeMPO Home Exercise Program, Motivational SMS Messages, In-Clinic Topical Therapy, In-Clinic Exercise Therapy
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. The ageing meniscus: Pathophysiology, epidemiology and management.Journal of experimental orthopaedics · 2026
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Jeffrey N KatzBrigham and Women's Hospital, Harvard Medical School, Boston.
Jamie E CollinsBrigham and Women's Hospital, Harvard Medical School, Boston.
Leslie BissonUniversity at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY.
Morgan H JonesBrigham and Women's Hospital, Harvard Medical School, Boston.
James J IrrgangUniversity of Pittsburgh School of Medicine, Pittsburgh.
Faith SelzerBrigham and Women's Hospital, Harvard Medical School, Boston.
Clare E Safran-NortonBrigham and Women's Hospital, Harvard Medical School, Boston.
Kurt P SpindlerCleveland Clinic Lerner College of Medicine, Cleveland.
Heidi Y YangBrigham and Women's Hospital, Harvard Medical School, Boston.
Swastina ShresthaBrigham and Women's Hospital, Harvard Medical School, Boston.
Kim L BennellDepartment of Physiotherapy, University of Melbourne, Parkville, VIC, Australia.ORCID 0000-0003-4982-5639
James K SullivanBrigham and Women's Hospital, Harvard Medical School, Boston.
Melissa A KluczynskiUniversity at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY.
Kaetlyn ArantBrigham and Women's Hospital, Harvard Medical School, Boston.
Maame Opare-AddoBrigham and Women's Hospital, Harvard Medical School, Boston.
Jamie L HuizingaBrigham and Women's Hospital, Harvard Medical School, Boston.
Zoe ZimmermanBrigham and Women's Hospital, Harvard Medical School, Boston.
Derek SopleBrigham and Women's Hospital, Harvard Medical School, Boston.
Peter TonsolineUniversity at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY.
Madhuri KaleBrigham and Women's Hospital, Harvard Medical School, Boston.
William M WindUniversity at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY.
Antonia F ChenUniversity of Texas Southwestern Medical Center, Dallas.
Michael FreitasUniversity at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY.
Bryson LesniakUniversity of Pittsburgh School of Medicine, Pittsburgh.
Kelly JordanUniversity at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY.
Elizabeth G MatzkinBrigham and Women's Hospital, Harvard Medical School, Boston.
Courtney DawsonBrigham and Women's Hospital, Harvard Medical School, Boston.
Lutul FarrowCleveland Clinic Lerner College of Medicine, Cleveland.
Volker MusahlUniversity of Pittsburgh School of Medicine, Pittsburgh.
John J LeddyUniversity at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY.ORCID 0000-0002-0370-1289
Scott D MartinMassachusetts General Hospital, Boston.
Elena LosinaBrigham and Women's Hospital, Harvard Medical School, Boston.

Funding

VERITY: Value and Evidence in Rheumatology using bioInformaTics, and advanced analYticsP30AR072577 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Elena Losina · 2017 to 2026
$9.8M
Treatment of Meniscal Problems in Osteoarthritis: TeMPOU01AR071658 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KATZ, JEFFREY NEIL · 2017 to 2022
$4.1M
Randomized Trial of Non-Operative Therapies for Degenerative Meniscal TearU34AR067426 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KATZ, JEFFREY NEIL · 2015 to 2016
$741k
Pain sensitization in a trial of physical therapy for osteoarthritis and meniscal tearR21AR076156 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KATZ, JEFFREY NEIL · 2019 to 2020
$616k
Data-driven approaches in defining knee osteoarthritis phenotypes and factorsassociated with fast progressionK01AR075879 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI COLLINS, JAMIE E. · 2020 to 2023
$524k
NIAMS NIH HHS K01 AR075879NIAMS NIH HHS P30 AR072577NIAMS NIH HHS R21 AR076156NIAMS NIH HHS U01 AR071658NIAMS NIH HHS U34 AR067426
6 · The paper itself

Abstract

backgroundPhysical therapy is routinely recommended for knee pain attributed to a degenerative meniscal tear, but its efficacy has not been established.

methodsWe randomly assigned participants 45 to 85 years of age with knee pain, osteoarthritis, and meniscal tear to one of four groups: home exercise (3-month home-exercise program), home exercise plus text messages to encourage exercise adherence, home exercise plus text messages plus sham physical therapy (in-clinic sham manual therapy and sham ultrasound therapy), and home exercise plus text messages plus standard physical therapy (supervised strengthening, functional, and stretching exercises and manual therapy). The primary outcome was the change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) pain subscore (range, 0 to 100, with higher scores indicating more pain) between baseline and 3 months, with adjustment for trial site, baseline KOOS pain subscore, and radiographic grade.

resultsA total of 879 participants underwent randomization (mean [±SD] age, 59.2±7.8 years). The difference in the 3-month change in the KOOS pain subscore between home exercise and home exercise plus text messages was -0.1 points (98.3% confidence interval [CI], -3.8 to 3.7) and between home exercise and home exercise plus text messages plus standard physical therapy was 2.5 points (98.3% CI, -1.3 to 6.2); the difference between home exercise plus text messages and home exercise plus text messages plus standard physical therapy was 2.5 points (98.3% CI, -1.4 to 6.5). Adverse events were generally nonserious and evenly distributed overall across groups.

conclusionsFor patients with degenerative meniscal tear and knee pain, the addition of physical therapy or text messages to encourage adherence to home exercises was not superior in reducing pain to a home-exercise program alone. (Funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases and others; TeMPO ClinicalTrials.gov number, NCT03059004.).

Indexed as

ArthralgiaExercise TherapyOsteoarthritis, KneeText MessagingTibial Meniscus InjuriesAgedFemaleHome Care ServicesHumansMaleMiddle AgedMusculoskeletal ManipulationsPain MeasurementTreatment OutcomeUltrasonic Therapy

Identifiers

PMID41160820
PMCPMC12614259

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.