Evidence map›Paper›PMID 41160695›Full record

ArticleScience advances2025

Tumor-derived RAC1

Mingjun Cai, Mike Adam, Xin Duan, Fukun Guo, Yi Zheng

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mingjun CaiGraduate Program of Development, Stem Cells, and Regenerative Medicine, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.ORCID 0000-0003-2987-2681
Mike AdamDivision of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.ORCID 0000-0003-4501-4740
Xin DuanDivision of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
Fukun GuoDivision of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
Yi ZhengGraduate Program of Development, Stem Cells, and Regenerative Medicine, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.ORCID 0000-0001-7089-6074

Funding

Novel Strategies to Improve Blood Transfusion PracticeP01HL158688 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Hongbo R Luo · 2022 to 2026
$12.9M
Xenotransplant and Genome Editing CoreU54DK126108 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Daniel Starczynowski, YI ZHENG · 2021 to 2026
$5.0M
Rational targeting of Cdc42 to benefit immunotherapyR01CA278756 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI Fukun Guo, YI ZHENG · 2024 to 2026
$1.8M
NCI NIH HHS R01 CA278756NHLBI NIH HHS P01 HL158688NIDDK NIH HHS U54 DK126108
6 · The paper itself

Abstract

RAC1

Indexed as

Immune Checkpoint InhibitorsMutationNeoplasmsNeuropeptidesrac1 GTP-Binding ProteinTumor MicroenvironmentAnimalsCell Line, TumorHumansMechanistic Target of Rapamycin Complex 1MiceProgrammed Cell Death 1 ReceptorSignal TransductionTOR Serine-Threonine KinasesImmune Checkpoint InhibitorsMechanistic Target of Rapamycin Complex 1NeuropeptidesProgrammed Cell Death 1 Receptorrac1 GTP-Binding ProteinRAC1 protein, humanRac1 protein, mouseTOR Serine-Threonine Kinases

Identifiers

PMID41160695
PMCPMC12571076

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.