Evidence map›Paper›PMID 41160686›Full record

ArticleScience advances2025

Bacteriophage-loaded microneedle patches for targeted and minimally disruptive foodborne pathogen decontamination.

Akansha Prasad, Shadman Khan, Fatima Arshad, Hareet Sidhu, Kyle Jackson, Roderick MacLachlan, Ekaterina Kvitka, Veronica Grignano, Hannah Mann, Carlos D M Filipe and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Akansha PrasadSchool of Biomedical Engineering, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-2636-5097
Shadman KhanSchool of Biomedical Engineering, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-5088-3441
Fatima ArshadSchool of Interdisciplinary Science, McMaster University, Hamilton, ON, Canada.
Hareet SidhuDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.
Kyle JacksonDepartment of Chemical Engineering, McMaster University, Hamilton, ON, Canada.
Roderick MacLachlanDepartment of Engineering Physics, McMaster University, Hamilton, ON, Canada.
Ekaterina KvitkaDepartment of Chemical Engineering, McMaster University, Hamilton, ON, Canada.ORCID 0009-0004-4715-352X
Veronica GrignanoFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Hannah MannDepartment of Chemical Engineering, McMaster University, Hamilton, ON, Canada.ORCID 0009-0003-9595-0569
Carlos D M FilipeDepartment of Chemical Engineering, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-7410-3323
Zeinab HosseinidoustDepartment of Chemical Engineering, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-9261-7611
Tohid F DidarSchool of Biomedical Engineering, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-8757-8002

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibacterial additive use has surged because of rising incidences of food contamination despite concerns over antibiotic resistance. Bacteriophage (bacterial viruses) is a promising alternative with pathogen-level specificity. However, their commercial success has been limited by the considerable diffusion barriers they face within food, preventing effective delivery at contamination sites. Here, we introduce bacteriophage-loaded microneedle patches that enable targeted phage delivery directly within food, eliminating internal pathogens in a minimally disruptive manner. The application of microneedles within food is first explored. The platform is then substantiated by comparing performance in raw beef and cooked chicken, where we achieved up to 3-log reduction in

Indexed as

BacteriophagesDecontaminationFoodborne DiseasesFood MicrobiologyNeedlesAnimalsChickensEscherichia coliFood Contamination

Identifiers

PMID41160686
PMCPMC12571077

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.