Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
31 authors.
Miriam M FonsecaPain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0003-0738-2577
Oriana GelblungPain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Sarah D PennypackerPain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0002-4777-747X
Taylor BrooksSection on Hematology and Oncology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0009-0007-4352-9296
Michael LimiaDepartment of Neurology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0009-0003-0740-3769
James W MorganPain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Xuewei ZhuSection on Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0002-8606-0930
Luis C Tovias-SanchezPain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Alejandro Pluma-PlumaPain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0003-4829-9948
Ruth Elena MartinezPain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0009-0006-5704-0996
Mathew R EberPain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0009-0008-9678-6568
Sun H ParkPain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Cristina M FurduiSection on Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0003-3771-7999
Deepika AwasthiDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0001-7125-9405
Alexander EmmanuelliDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0002-7937-7681
Byuri A ChoPrecision Immunology Institute, Hess Center for Science and Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-1802-7709
Chen TanDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0003-0521-8044
David I ShalowitzDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0002-5189-4687
Samuel S LentzDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0001-6397-6383
Michael KellyDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Anderson O'Brien CoxProteomics and Metabolomics Shared Resource, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0001-5491-1019
Lindsay MacnamaraProteomics and Metabolomics Shared Resource, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0002-0819-8109
Fang-Chi HsuDivision of Public Health Sciences, Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0002-3310-184X
Yusuke ShiozawaDepartment of Cancer Biology and Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
Wesley HsuDepartment of Neurosurgery, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0001-7492-4837
Takao IwawakiDivision of Cell Medicine, Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan.ORCID 0000-0001-8753-1979
Lance D MillerDepartment of Cancer Biology and Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.ORCID 0000-0003-3799-2528
Glenn J LesserDepartment of Cancer Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0009-0003-5471-8907
Roy StrowdDepartment of Neurology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0001-6651-5267
Juan R Cubillos-RuizDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0002-4267-4893
E Alfonso Romero-SandovalPain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0002-3859-8023
Funding
Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
ER stress-driven IRE1a-XBP1 signaling in lung cancerR01CA271619 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Juan R Cubillos-Ruiz, Vivek Mittal · 2023 to 2026
$2.6M
Endoplasmic Reticulum Stress Responses in PainR01NS114653 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BOADA, MARIO DANILO, ROMERO-SANDOVAL, E. ALFONSO · 2020 to 2024
$2.0M
The contributions of sensory nerves to bone metastasis and associated bone painR01CA238888 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SHIOZAWA, YUSUKE · 2020 to 2024
$1.8M
Molecular Programs Governing Enterococcal TranslocationR01AI184474 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Juan R Cubillos-Ruiz, Diana K. Morales · 2025 to 2026
$1.7M
IRE1a-XBP1 Signaling as a Driver of Chemotherapy-Induced Peripheral NeuropathyR21CA248106 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CUBILLOS-RUIZ, JUAN R, ROMERO-SANDOVAL, E. ALFONSO · 2020 to 2021
$420k
Immunosuppressive Programs Driven by IRE1 signaling in ovarian cancerF31CA257631 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI EMMANUELLI, ALEXANDER · 2021 to 2023
Chemotherapy-induced peripheral neuropathy (CIPN) is the most prevalent and limiting side effect of paclitaxel treatment in patients with cancer. CIPN affects sensory neurons through neuroinflammatory mechanisms, but how immune cells sense and interpret systemic paclitaxel exposure during treatment is unclear. Here, we found that paclitaxel administration activated the endoplasmic reticulum (ER) stress sensor inositol-requiring enzyme 1α (IRE1α) in circulating and dorsal root ganglion-resident myeloid cells, engendering an inflammatory milieu that promotes CIPN. Mechanistically, paclitaxel induced the overproduction of mitochondria-derived reactive oxygen species (ROS) that provoked ER stress and IRE1α hyperactivation in macrophages. This process reprogrammed macrophages toward an inflammatory state characterized by IRE1α-dependent production of TNF-α, IL-1β, PGE
Indexed as
Antineoplastic AgentsEndoplasmic Reticulum StressLeukocytesPeripheral Nervous System DiseasesAnimalsEndoribonucleasesFemaleGanglia, SpinalHumansInflammationMacrophagesMaleMiceMice, Inbred C57BLPaclitaxelProtein Serine-Threonine KinasesAntineoplastic AgentsEndoribonucleasesERN1 protein, humanPaclitaxelProtein Serine-Threonine KinasesReactive Oxygen Species
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy. · full record | OpenQuestion