Evidence map›Paper›PMID 41160600›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

p53 regulates the expression of histone modifiers to restrict stemness and maintain differentiated luminal identity in breast cancer.

Yael Aylon, Noa Furth, Anna C Pirona, Adi Lavie, Olga Fedorova, Ori Hassin, Nuno Padrão, Maxime Steinmetz, Avital Sarusi-Potuguez, Liat Fellus-Alyagor and 5 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yael Aylon *Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Noa Furth *Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID 0000-0001-8728-519X
Anna C PironaDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Adi LavieDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Olga FedorovaDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Ori HassinDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Nuno PadrãoDivision of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands.ORCID 0000-0002-8368-2806
Maxime SteinmetzDivision of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands.
Avital Sarusi-PotuguezNancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot 7610001, Israel.
Liat Fellus-AlyagorDepartment of Veterinary Resources, Weizmann Institute of Science, Rehovot 7610001, Israel.
Irit ShimoniDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Bareket DassaDepartment of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot 7610001, Israel.
Wilbert ZwartDivision of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands.ORCID 0000-0002-9823-7289
Efrat ShemaDepartment of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID 0000-0002-3718-593X
Moshe OrenDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID 0000-0003-4311-7172

Funding

Alpe d'HuZes 12018Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (AMRF) G-201906-00324Dutch Cancer Society not specifiedEC | ERC | HORIZON EUROPE European Research Council (ERC) ERC101115455Emerson Collective (Emerson) not specifiedERA-NET not specifiedFabrikant-Morse Families Research Fund for Humanity not specifiedGerman-Israeli Cooperation in Cancer Research CA-209German-Israeli Cooperation in Cancer Research not specifiedGuilford Glazer Foundation Acceleration Grant 1263267Israel Cancer Research Fund (ICRF) 839119Israel Science Foundation (ISF) 1349/24Morris Kahn Institute for Human Immunology not specifiedQuinquin Foundation not specifiedTranscan (Transcan-3) not specified
6 · The paper itself

Abstract

Breast cancer is the leading cause of death in women under 50. The majority of breast cancers are estrogen receptor α-positive (ER+) and are commonly treated with hormonal therapies such as tamoxifen that inhibit ER activity. The

Indexed as

Breast NeoplasmsGene Expression Regulation, NeoplasticHistonesNeoplastic Stem CellsTumor Suppressor Protein p53Cell DifferentiationCell Line, TumorChromatinDrug Resistance, NeoplasmEstrogen Receptor alphaFemaleHumansTamoxifenChromatinEstrogen Receptor alphaHistonesTamoxifenTP53 protein, humanTumor Suppressor Protein p53breast cancerestrogen receptorhistone modificationp53tamoxifen

Identifiers

PMID41160600
PMCPMC12595495

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.