Evidence map›Paper›PMID 41160506›Full record

ArticleJournal of Huntington's disease2026

Huntingtin knockdown dysregulates autophagic degradation of Apolipoprotein E.

Gianna M Fote, Nicolette R McClure, Robert M Bragg, Jharrayne McKnight, Leslie M Thompson, Jeffrey B Carroll, Joan S Steffan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Huntington's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gianna M FoteDepartment of Biological Chemistry, University of California Irvine, Irvine, CA, USA.ORCID 0000-0002-1854-7894
Nicolette R McClureDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.ORCID 0000-0002-3251-1441
Robert M BraggDepartment of Neurology, University of Washington, Seattle, WA, USA.ORCID 0000-0003-0619-8954
Jharrayne McKnightDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.ORCID 0000-0002-3533-1753
Leslie M ThompsonDepartment of Biological Chemistry, University of California Irvine, Irvine, CA, USA.ORCID 0000-0003-4573-9514
Jeffrey B CarrollDepartment of Neurology, University of Washington, Seattle, WA, USA.ORCID 0000-0003-1711-8868
Joan S SteffanDepartment of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.ORCID 0000-0003-2467-6294

Funding

UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI YASSA, MICHAEL A · 2000 to 2019
$37.0M
Training in the Neurobiology of Aging and Alzheimers DiseaseT32AG000096 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI VIVEK SWARUP, Craig E Stark · 1985 to 2026
$9.6M
Molecular Mechanisms of Pathogenesis in Huntington’s diseaseR35NS116872 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Leslie Michels Thompson · 2020 to 2026
$8.5M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1M
Neuroregulatory Mechanisms of PIAS1 and Implications for Huntington's DiseaseR01NS090390 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAVIDSON, BEVERLY L., THOMPSON, LESLIE MICHELS · 2015 to 2018
$1.8M
Pathogenic impact of Huntington phosphorylation in Huntington's DiseaseR01NS072453 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI STEFFAN, JOAN SAWYER · 2012 to 2015
$1.3M
Neuroregulatory Mechanisms of PIAS1 and Implications for Huntington's DiseaseR56NS090390 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI THOMPSON, LESLIE MICHELS · 2014 to 2014
$565k
Pathogenic impact of Huntingtin phosphorylation in Huntington's DiseaseR56NS072453 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI STEFFAN, JOAN SAWYER · 2017 to 2017
$377k
Defining the Function of APOE in Autophagy and NeurodegenerationF30AG060704 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI FOTE, GIANNA · 2019 to 2021
$131k
NIA NIH HHS F30 AG060704NIA NIH HHS P50 AG016573NIA NIH HHS T32 AG000096NIGMS NIH HHS T32 GM008620NINDS NIH HHS R01 NS072453NINDS NIH HHS R01 NS090390NINDS NIH HHS R35 NS116872NINDS NIH HHS R56 NS072453NINDS NIH HHS R56 NS090390
6 · The paper itself

Abstract

BackgroundThe HTT protein, mutated in Huntington's disease, is expressed throughout the body, and loss of HTT function as an autophagic scaffold may affect tissues and cellular processes. These processes include lipid metabolism potentially regulated upstream by Apolipoprotein E (APOE) and clearance of APOE itself.ObjectiveTo determine the impact of HTT reduction on autophagy and clearance of APOE in cell culture and in mouse liver

Indexed as

Apolipoproteins EAutophagyChaperone-Mediated AutophagyHuntingtin ProteinHuntington DiseaseLiverAnimalsGene Knockdown TechniquesHep G2 CellsHumansLysosomal-Associated Membrane Protein 2MiceMice, KnockoutApolipoproteins EHTT protein, humanHtt protein, mouseHuntingtin ProteinLysosomal-Associated Membrane Protein 2apolipoprotein Echaperone-mediated autophagyHuntingtinHuntington's diseaselivermacroautophagy

Identifiers

PMID41160506
PMCPMC12847462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.