Evidence map›Paper›PMID 41160432›Full record

ArticleMolecular biology of the cell2026

Strained actin binding by the Prickle2 LIM domains and their regulation in the full-length protein.

Vidal Bejar-Padilla, Mindy Li, Jeanne C Stachowiak, John B Wallingford

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Vidal Bejar-PadillaDepartment of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.
Mindy LiDepartment of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.
Jeanne C StachowiakDepartment of Biomedical Engineering, University of Texas, Austin, TX 78712, USA.
John B WallingfordDepartment of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.

Funding

Protein Networks as Synergistic Drivers of Membrane RemodelingR35GM139531 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Jeanne Casstevens Stachowiak · 2021 to 2026
$4.0M
Molecular and cell biological basis of convergent extensionR01HD099191 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI John B Wallingford · 2020 to 2026
$2.7M
Democratizing embryo biomechanics: Development of robust and accessible methods to quantify sub-cellular mechanics in vivoR21HD112657 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI ALVARADO, JOSE R, WALLINGFORD, JOHN B · 2023 to 2023
$436k
NICHD NIH HHS R01 HD099191NICHD NIH HHS R01HD099191-08SNICHD NIH HHS R21 HD112657NIGMS NIH HHS R35 GM139531
6 · The paper itself

Abstract

Cells sense mechanical changes in their cytoskeletal network via force-sensing actin-binding proteins. Recently, a novel force-sensing mechanism was described whereby Lin11, Isl- 1, and Mec-3 (LIM) domains from diverse protein families bind directly to strained actin filaments. It remains unclear, however, how the interaction of these domains with actin is regulated in the context of full-length proteins. Here, we show that the LIM domain-containing region (LCR) of the planar cell polarity protein Prickle2 (Pk2) is associated with strained actin filaments in

Indexed as

ActinsLIM Domain ProteinsXenopus ProteinsActin CytoskeletonAnimalsCell PolarityHumansMicrofilament ProteinsProtein BindingProtein DomainsXenopus laevisActinsLIM Domain ProteinsMicrofilament ProteinsXenopus Proteins

Identifiers

PMID41160432
PMCPMC12699789

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.