Evidence map›Paper›PMID 41160327›Full record

ArticleJournal of cardiovascular translational research2025

A Potential Ratio for Detecting Subclinical Atherosclerosis: Insight into Advanced NMR Lipid Profiles in Severe Obesity.

Júlia Carmona-Maurici, Iratxe Eskubi-Turró, Anna Viñas, David Ricart-Jané, Mª Dolores López-Tejero, Núria Amigó, Marcelino Bermúdez, Juan Antonio Baena-Fustegueras, Julia Peinado-Onsurbe, Eva Pardina

Abstract read
In one paragraph

Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Júlia Carmona-MauriciDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Diagonal 643, 08028, Barcelona, Spain.
Iratxe Eskubi-TurróDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Diagonal 643, 08028, Barcelona, Spain.
Anna ViñasDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Diagonal 643, 08028, Barcelona, Spain.
David Ricart-JanéDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Diagonal 643, 08028, Barcelona, Spain.
Mª Dolores López-TejeroDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Diagonal 643, 08028, Barcelona, Spain.
Núria AmigóSpanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain.
Marcelino BermúdezVascular and Renal Translational Research Group, IRBLleida, Lleida, Spain.
Juan Antonio Baena-FusteguerasEndocrinology Surgery Unit, Arnau de Vilanova University Hospital (UdL), Lleida, Spain.
Julia Peinado-OnsurbeDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Diagonal 643, 08028, Barcelona, Spain.
Eva PardinaDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Diagonal 643, 08028, Barcelona, Spain. epardina@ub.edu.ORCID 0000-0002-0588-1324

Funding

Instituto de Salud Carlos III PI15/00190
6 · The paper itself

Abstract

Individuals with severe obesity (SO) are at a high risk of developing cardiovascular disease, but traditional lipid parameters are insufficient for accurately assessing the risk. This study aims to investigate the advanced characteristics of lipoproteins that may contribute to subclinical atherosclerosis in SO and the impact of bariatric surgery (BS). The study included 37 patients with SO with a one-year follow-up post-BS, and 40 control subjects. Advanced lipoprotein profiles were assessed using nuclear magnetic resonance. BS normalized proatherogenic lipoprotein alterations in SO. Small LDL and medium HDL particle numbers differed between plaque and non-plaque groups. A ratio of these particles showed an AUC of 83%, suggesting it could effectively predict subclinical atherosclerosis. Advanced NMR analysis offers more specific information on lipid profiles in SO. The small LDL-P to medium HDL-P ratio could be a valuable tool for detecting and managing subclinical atherosclerosis in this population.

Indexed as

AtherosclerosisLipidsObesity, MorbidAdultAsymptomatic DiseasesBariatric SurgeryBiomarkersCase-Control StudiesFemaleHumansMagnetic Resonance SpectroscopyMaleMiddle AgedPlaque, AtheroscleroticPredictive Value of TestsTime FactorsBiomarkersLipidsAtherosclerosisBariatric surgeryLipoproteinsNuclear magnetic resonanceSevere obesity

Identifiers

PMID41160327
PMCPMC12700994

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.