Evidence map›Paper›PMID 41160280›Full record

Observational studyNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

CT perfusion in the acute setting: a useful tool in the differential diagnosis of aphasic syndromes.

Giovanni Furlanis, Emanuele Vincis, Edoardo Ricci, Milos Ajčević, Federica Palacino, Gianpiero Farina, Gabriele Prandin, Laura Mancinelli, Magda Quagliotto, Alina Menichelli and 6 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. CT Perfusion in lacunar stroke: a powerful tool to enhance lacunar stroke detection and prediction of patients' outcome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Giovanni FurlanisClinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, Trieste University Hospital ASUGI, University of Trieste, Strada di Fiume, Trieste, 447-34149, Italy. giovanni.furlanis@asugi.sanita.fvg.it.ORCID http://orcid.org/0000-0002-9954-0239
Emanuele VincisClinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, Trieste University Hospital ASUGI, University of Trieste, Strada di Fiume, Trieste, 447-34149, Italy.
Edoardo RicciClinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, Trieste University Hospital ASUGI, University of Trieste, Strada di Fiume, Trieste, 447-34149, Italy.
Milos AjčevićClinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, Trieste University Hospital ASUGI, University of Trieste, Strada di Fiume, Trieste, 447-34149, Italy.
Federica PalacinoClinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, Trieste University Hospital ASUGI, University of Trieste, Strada di Fiume, Trieste, 447-34149, Italy.
Gianpiero FarinaClinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, Trieste University Hospital ASUGI, University of Trieste, Strada di Fiume, Trieste, 447-34149, Italy.
Gabriele PrandinClinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, Trieste University Hospital ASUGI, University of Trieste, Strada di Fiume, Trieste, 447-34149, Italy.
Laura MancinelliClinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, Trieste University Hospital ASUGI, University of Trieste, Strada di Fiume, Trieste, 447-34149, Italy.
Magda QuagliottoClinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, Trieste University Hospital ASUGI, University of Trieste, Strada di Fiume, Trieste, 447-34149, Italy.
Alina MenichelliRehabilitation Unit, Department of Medicine, Surgery and Health Sciences, Trieste University Hospital-ASUGI, University of Trieste, Trieste, Italy.
Paola PotenteClinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, Trieste University Hospital ASUGI, University of Trieste, Strada di Fiume, Trieste, 447-34149, Italy.
Martina MasetClinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, Trieste University Hospital ASUGI, University of Trieste, Strada di Fiume, Trieste, 447-34149, Italy.
Paola CarusoClinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, Trieste University Hospital ASUGI, University of Trieste, Strada di Fiume, Trieste, 447-34149, Italy.
Marcello NaccaratoClinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, Trieste University Hospital ASUGI, University of Trieste, Strada di Fiume, Trieste, 447-34149, Italy.
Maja UkmarRadiology Unit, Department of Medicine, Surgery and Health Sciences, Trieste University Hospital ASUGI, University of Trieste, Strada di Fiume, Trieste, 447-34149, Italy.
Paolo ManganottiClinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, Trieste University Hospital ASUGI, University of Trieste, Strada di Fiume, Trieste, 447-34149, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAcute-onset aphasia is a common condition in ischemic stroke but it can also occur in other conditions defined as stroke mimics (SM). CT perfusion (CTP) is a radiological tool employed during the "stroke code" but its role in differentiating patients with stroke from those with SM is still under investigation. We aimed to evaluate the role of CTP in the differential diagnosis between stroke-related aphasia and SM-related aphasia in the acute setting. MATERIALS AND

methodsIn this retrospective observational study conducted at Trieste University Hospital, we compared demographic, clinical, and imaging data of patients with stroke-related aphasia and patients with SM-related aphasia, differentiating the two groups according to the presence or absence of an ischemic lesion at the follow-up CT/MRI. Ischemic pattern was defined as regions of perfusion asymmetries following cerebral arteries' supply territories with MTT prolongation, decreased CBV, decreased CBF or summary map showing penumbra/core, while non-ischemic pattern was defined as regions of perfusion asymmetries not classifiable as ischemic pattern as stated above or as the absence of CTP asymmetries.

resultsOut of 140 patients analyzed, 116 (83%) received a final diagnosis of stroke-related aphasia, while 24 were diagnosed with SM-related aphasia (17%). MTT was the most useful CTP map in identifying an ischemic pattern in patients with stroke-related aphasia (detection rate 95.69%). DISCUSSION: CTP is an appropriate radiological tool for making an accurate etiological diagnosis in the context of aphasic syndromes. MTT map was found to be the most accurate in identifying an ischemic pattern.

Indexed as

AphasiaIschemic StrokePerfusion ImagingStrokeTomography, X-Ray ComputedAgedAged, 80 and overCerebrovascular CirculationDiagnosis, DifferentialFemaleHumansMaleMiddle AgedRetrospective StudiesAphasiaCT perfusionCT-scanIschemic strokeStroke mimic

Identifiers

PMID41160280

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.