Evidence map›Paper›PMID 41160270›Full record

ReviewJournal of neuro-oncology2025

The activity of cold atmospheric plasma against high-grade glioma: a review.

Sophie Peeters, Wi Jin Kim, Amber Armellini, Blake Haist, Weihong Ge, Zhitong Chen, Richard Obenchain, Graeme Sabiston, Peter Wu, George I Ayad and 4 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sophie PeetersDepartment of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, 300 Stein Plaza, Suite 420, Los Angeles, CA, 90095, USA.
Wi Jin KimDepartment of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, 300 Stein Plaza, Suite 420, Los Angeles, CA, 90095, USA.
Amber ArmelliniDepartment of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, 300 Stein Plaza, Suite 420, Los Angeles, CA, 90095, USA.
Blake HaistDepartment of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, USA.
Weihong GeDepartment of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA.
Zhitong ChenDepartment of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, USA.
Richard ObenchainDepartment of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, USA.
Graeme SabistonDepartment of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, USA.
Peter WuDepartment of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, 300 Stein Plaza, Suite 420, Los Angeles, CA, 90095, USA.
George I AyadDepartment of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, 300 Stein Plaza, Suite 420, Los Angeles, CA, 90095, USA.
Robert M PrinsDepartment of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, 300 Stein Plaza, Suite 420, Los Angeles, CA, 90095, USA.
Aparna BhaduriDepartment of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, 300 Stein Plaza, Suite 420, Los Angeles, CA, 90095, USA.
Richard WirzDepartment of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, USA.
Anthony C WangDepartment of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, 300 Stein Plaza, Suite 420, Los Angeles, CA, 90095, USA. ACWang@mednet.ucla.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCold atmospheric plasma (CAP), a partially ionized near-room temperature gas (argon or helium), generates a variety of oxygen and nitrogen reactive species which can have a multitude of downstream biological effects including cell death, inflammation, and immune modulation. CAP is therefore a powerful tool with many potential medical applications, particularly in cancer treatment. As primary treatment, CAP can be administered directly through a plasma jet, or indirectly via plasma activated substances (i.e. media, biogels, etc.). CAP has been shown to directly kill cancer cells by inducing RONS-mediated cell death mechanisms, enhance anti-tumor immunity or increase the tumor's responsiveness to systemic therapies. While the chemical factors (i.e. RONS-mediated apoptosis) is the most studied mechanism of CAP efficacy, CAP can also induce necrosis of cells through ultraviolet irradiation, thermal and electromagnetic effects, which tend to lead to necrosis. CAP has been shown to cause selective cell death in various cancers, including skin, breast, colorectal, head and neck, and more recently in gliomas, with minimal side effects to surrounding normal tissues.

conclusionWe summarize the studies investigating CAP applications in neuro-oncology to date, including in vitro and pre-clinical studies, followed by a brief mention of ongoing clinical trials for CAP as a cancer treatment.

Indexed as

Brain NeoplasmsGliomaPlasma GasesAnimalsHumansPlasma GasesCancer therapyCold atmospheric plasmaCytotoxicGlioblastomaReactive oxygen species

Identifiers

PMID41160270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.