Evidence map›Paper›PMID 41160245›Full record

ArticleInternational urology and nephrology2026

Asymptomatic versus symptomatic ureteral stones: predictors and nomogram for postoperative renal function recovery.

Mingbin Xu, Guoliang Wu, Daoyuan Li, Shuming He, Chengyang Li

Abstract readComparative StudyMulticenter Study
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Article in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Mingbin Xu *Department of Urology, The Second Affiliated Hospital of Hainan Medical University, Hainan, China.
Guoliang Wu *Department of Urology, The Second Affiliated Hospital of Hainan Medical University, Hainan, China.
Daoyuan LiDepartment of Urology, Hainan Provincial People's Hospital, Hainan, China.
Shuming HeDepartment of Urology, The Second Affiliated Hospital of Hainan Medical University, Hainan, China.
Chengyang LiDepartment of Urology, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China. assheep@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare renal function outcomes between asymptomatic and symptomatic ureteral stones and to develop and validate a predictive nomogram for postoperative renal recovery after ureteroscopic lithotripsy (URSL).

methodsThis two-center retrospective study included consecutive patients who underwent URSL between March 2018 and March 2023. Patients were categorized into asymptomatic and symptomatic groups. Renal function recovery was defined as a postoperative glomerular filtration rate (GFR) of the affected kidney exceeding 90% of the contralateral side at 1 year. Predictors were identified by logistic regression and incorporated into a nomogram. Model performance was assessed by receiver operating characteristic (ROC) analysis, calibration, and decision curve analysis (DCA), with both internal (bootstrap resampling) and external validation.

resultsAmong 635 patients who underwent URSL, 465 (73.2%) demonstrated recovery of renal function at 1 year postoperatively. Asymptomatic stones (n = 38, 5.98%) were associated with larger size, upper ureteral location, severe hydronephrosis, and lower preoperative GFR compared with symptomatic stones. Multivariate logistic regression identified six independent predictors of renal function recovery: older age, diabetes mellitus, higher hydronephrosis grade, complete obstruction, lower preoperative split renal function, and symptomatic status (all p < 0.05). The nomogram incorporating these variables demonstrated good discrimination (AUC = 0.786) and calibration (MAE = 0.02), which was confirmed by external validation (AUC = 0.805; MAE = 0.03). Decision curve analysis (DCA) further indicated superior clinical net benefit across a wide range of threshold probabilities.

conclusionsAsymptomatic ureteral stones were associated with delayed diagnosis, advanced obstruction, and limited renal recovery. The proposed nomogram provides a validated, individualized tool to estimate recovery probability and may inform early surgical intervention strategies.

Indexed as

KidneyLithotripsyNomogramsUreteral CalculiUreteroscopyAdultAgedAsymptomatic DiseasesFemaleGlomerular Filtration RateHumansMaleMiddle AgedPostoperative PeriodPredictive Value of TestsRecovery of FunctionAsymptomatic ureteral stonesPredictRenal functionUreteroscopic lithotripsy

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.