Evidence map›Paper›PMID 41160211›Full record

ArticleImmunologic research2025

SerpinB9 sustains CIITA to orchestrate MHC-II expression and Th1 differentiation in β-glucan-induced macrophages.

Xin Huang, Jun Ding, Yongzhe Hao, Jie Pan, Meng Yuan, Fang Shao, Yewen Xie, Zhichao Zhu, Chunjian Qi

Abstract read
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In one paragraph

Article in Immunologic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xin HuangLaboratory of Oncology, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, P.R. China.
Jun DingLaboratory of Oncology, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, P.R. China.
Yongzhe HaoLaboratory of Oncology, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, P.R. China.
Jie PanLaboratory of Oncology, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, P.R. China.
Meng YuanLaboratory of Oncology, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, P.R. China.
Fang ShaoLaboratory of Oncology, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, P.R. China.
Yewen XieLaboratory of Oncology, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, P.R. China.
Zhichao ZhuLaboratory of Oncology, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, P.R. China.
Chunjian QiLaboratory of Oncology, Changzhou Medical Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, P.R. China. qichunjian@njmu.edu.cn.

Funding

National Natural Science Foundation of China 32270954Natural Science Foundation of Changzhou Municipality CJ20252040Natural Science Foundation of Jiangsu Province BE2023693
6 · The paper itself

Abstract

Whole glucan particles (WGP) enhance macrophage immune function, while serine protease inhibitor B9 (SerpinB9)-a molecule known to promote tumor immune escape-has an unclear role in WGP-induced macrophage function. In this study, we found that SerpinB9 knockout in WGP-induced bone marrow-derived macrophages (BMDMs) significantly downregulated surface MHC-II expression, reduced TNF-α secretion, and impaired their ability to induce Th1 cell differentiation. Transcriptome analysis revealed that CIITA, the core regulator of MHC-II transcription, was markedly downregulated in SerpinB9-knockout BMDMs. Further experiments confirmed that CIITA knockdown decreased BMDM surface MHC-II expression, whereas CIITA overexpression rescued MHC-II expression in SerpinB9-knockout BMDMs and restored their capacity to induce Th1 cell differentiation. In conclusion, this study demonstrates that under WGP induction, SerpinB9 regulates macrophage MHC-II expression and Th1 differentiation-inducing ability by maintaining CIITA expression, providing new insights into macrophage immune regulation mechanisms.

Indexed as

Histocompatibility Antigens Class IIMacrophagesNuclear ProteinsSerpinsTh1 CellsTrans-ActivatorsAnimalsCell DifferentiationCells, CulturedMiceMice, Inbred C57BLMice, KnockoutHistocompatibility Antigens Class IIMHC class II transactivator proteinNuclear ProteinsSerpinsTrans-ActivatorsCIITAImmune functionMacrophagesSerine protease inhibitor B9 (SerpinB9)Whole glucan particles (WGP)

Identifiers

PMID41160211

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.