Evidence map›Paper›PMID 41160185›Full record

ReviewMolecular biology reports2025

Activation and regulation of NAIP/NLRC4 and NLRP3 inflammasomes during Salmonella infection: mechanisms and therapeutic implications.

Yeling He, Dandan Ding, Jiayin Guo, Hui Sun, Jing Yang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Yeling HeCuiying Biomedical Research Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, Gansu, China.
Dandan DingCuiying Biomedical Research Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, Gansu, China.
Jiayin GuoCuiying Biomedical Research Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, Gansu, China.
Hui SunCuiying Biomedical Research Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, Gansu, China.
Jing YangCuiying Biomedical Research Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, Gansu, China. yangjing0502@lzu.edu.cn.

Funding

Cuiying Scientific and Technological Innovation Program of The Second Hospital & Clinical Medical School, Lanzhou University CY2021-MS-A05Fundamental Research Funds for the Central Universities lzujbky-2023-eyt04National Natural Science Foundation of China 82102431Talent Introduction Plan of The Second Hospital & Clinical Medical School, Lanzhou University yjrckyqdj-2021-03
6 · The paper itself

Abstract

Inflammasomes constitute a critical component of host defense against Salmonella infection, among which the NAIP/NLRC4 and NLRP3 complexes serve as the two principal signaling platforms. The NAIP/NLRC4 inflammasome functions as a rapid-response sensor that specifically recognizes bacterial flagellin and T3SS components, leading to caspase-1 activation, GSDMD-mediated pyroptosis, and IL-1β/IL-18 maturation. In contrast, NLRP3 integrates broad cellular stress signals, such as K

Indexed as

Apoptosis Regulatory ProteinsCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsInflammasomesNeuronal Apoptosis-Inhibitory ProteinNLR Family, Pyrin Domain-Containing 3 ProteinSalmonella InfectionsAnimalsHumansMiceSalmonellaSignal TransductionApoptosis Regulatory ProteinsCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsInflammasomesNAIP protein, humanNeuronal Apoptosis-Inhibitory ProteinNLRC4 protein, humanNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanCaspaseInflammasomeInflammasome-targeted immunotherapyNAIPNLRC4NLRP3PyroptosisSalmonella entericaType III secretion system (T3SS)

Identifiers

PMID41160185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.