Evidence map›Paper›PMID 41160176›Full record

ArticleWiener klinische Wochenschrift2026

Preoperative anemia, transfusions and survival in colorectal cancer surgery-A retrospective study.

Lorenz M Pammer, Messina Bath, Harald Schennach, Manfred Astl, Benedikt Schaefer, Sonja Wagner, Marlene Panzer, Elke Pertler, Dietmar Fries, Herbert Tilg and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Wiener klinische Wochenschrift, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lorenz M PammerDepartment of Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.ORCID http://orcid.org/0000-0001-9228-372X
Messina BathDepartment of Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Harald SchennachCentral Institute for Blood Transfusion and Department of Immunology (ZIB), Medical University of Innsbruck, Tirol Kliniken, Anichstraße 35, 6020, Innsbruck, Austria.
Manfred AstlCentral Institute for Blood Transfusion and Department of Immunology (ZIB), Medical University of Innsbruck, Tirol Kliniken, Anichstraße 35, 6020, Innsbruck, Austria.ORCID http://orcid.org/0009-0005-6616-3552
Benedikt SchaeferDepartment of Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.ORCID http://orcid.org/0000-0001-8690-2774
Sonja WagnerDepartment of Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.ORCID http://orcid.org/0000-0003-2319-2722
Marlene PanzerDepartment of Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.ORCID http://orcid.org/0000-0003-1957-412X
Elke PertlerDepartment of Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-1162-9571
Dietmar FriesDepartment of Anaesthesiology and Intensive care, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-1225-4214
Herbert TilgChristian Doppler Laboratory for Iron and Phosphate Biology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-4235-2579
Dietmar ÖfnerDepartment of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.ORCID http://orcid.org/0000-0001-8909-8566
Heinz ZollerDepartment of Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria. heinz.zoller@i-med.ac.at.ORCID http://orcid.org/0000-0003-1794-422X

Funding

Christian Doppler Forschungsgesellschaft Iron and Phosphate Biology
6 · The paper itself

Abstract

Perioperative anemia and blood transfusions are frequent and both are associated with a worse outcome in patients undergoing colorectal cancer surgery. To assess if treatment of anemia by transfusions can improve outcome, we conducted the present retrospective analysis.Of all patients who underwent elective colorectal cancer surgery at the University Hospital of Innsbruck between 2010 and 2019, 654 patients could be included in the study. The impact of preoperative anemia and transfusion on 1‑year survival was assessed using Kaplan-Meier analysis, univariate and multivariate Cox regression and inverse probability treatment weighting models to estimate the effects of preoperative transfusion on outcome.Preoperative anemia was present in 62.4% of patients and was the strongest predictor of perioperative transfusions. Intraoperative or postoperative transfusion occurred in 30.3% of the cohort, with higher rates in anemic patients. The transfusion rate was 36% between 2010 and 2015 and 25% in patients who underwent surgery from 2015 onwards.The 1‑year survival was significantly lower in transfused compared to nontransfused patients. After adjusting for age, sex and hemoglobin, transfusions and anemia were no longer independent predictors of survival. Elevated C‑reactive protein (CRP), higher tumor stage, age and minimally invasive surgery were identified as the main independent predictors of 1‑year mortality.Preoperative anemia predicts a higher rate of perioperative transfusions and is associated with worse 1‑year survival after colorectal cancer surgery. Transfusions do not correct impaired survival in patients with anemia. These findings underline the importance of proactive anemia management before surgery to improve postoperative outcome.

Indexed as

AnemiaBlood TransfusionColorectal NeoplasmsAgedAged, 80 and overColorectal Surgical ProceduresFemaleHumansMaleMiddle AgedPreoperative CareRetrospective StudiesSurvival RateAnaemiaIronIron-deficiencyPacked red blood cellsPatient blood management

Identifiers

PMID41160176

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.