ArticleEpigenetics2025
Integrative DNA methylation and transcriptome analysis reveal cell-type specific patterns in response to elevated allostatic load.
Article in Epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Immuno-inflammatory-metabolic interactions in cardiovascular diseases: a review from basic mechanisms to clinical translation.Frontiers in immunology · 2026Review
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Allostatic load (AL) is a measure of the body's multi-systemic physiological dysregulation in response to chronic stress and life events. High AL has been associated with poor long-term health outcomes such as cardiovascular disease and mortality. DNA methylation (DNAm) is an epigenetic mechanism involving both genes and environmental factors and contributes to gene expression regulation. Hence, changes in AL can possibly be reflected in DNAm and gene expression differences and leveraging epigenetic and transcriptomic data together can help elucidate the underlying biological processes involved. To assess differential DNAm and gene expression between high and low AL in a cell-type specific manner, bulk DNAm and transcriptome signals from whole blood samples of 429 individuals from the Swiss Kidney Project On Genes in Hypertension (SKIPOGH) cohort were first deconvoluted into cell-type specific signals for six blood cell types using tensor composition analysis (TCA) and the software CIBERSORTx. For each cell type, DNAm associated with gene expression changes was then determined in high (
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