Evidence map›Paper›PMID 41159756›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Fluorescence Visualization of Helix Inversion in Biomimic Polymeric Foldamer.

Yuan Qiu, Zonghang Liu, Chenchen Sun, Xilong Wei, Ryan T K Kwok, Yonggui Liao, Jianwei Sun, Jacky W Y Lam, Zijie Qiu, Xiaolin Xie and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Fluorescence Visualization of Helix Inversion in Biomimic Polymeric Foldamer.Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuan QiuDepartment of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, P.R. China.
Zonghang LiuGuangdong Basic Research Center of Excellence for Aggregate Science, School of Science and Engineering, The Chinese University of Hong Kong (Shenzhen), Longgang, Shenzhen, Guangdong, 518172, P.R. China.
Chenchen SunKey Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, P.R. China.
Xilong WeiGuangdong Basic Research Center of Excellence for Aggregate Science, School of Science and Engineering, The Chinese University of Hong Kong (Shenzhen), Longgang, Shenzhen, Guangdong, 518172, P.R. China.
Ryan T K KwokDepartment of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, P.R. China.
Yonggui LiaoKey Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, P.R. China.ORCID 0000-0003-2943-1501
Jianwei SunDepartment of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, P.R. China.
Jacky W Y LamDepartment of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, P.R. China.
Zijie QiuGuangdong Basic Research Center of Excellence for Aggregate Science, School of Science and Engineering, The Chinese University of Hong Kong (Shenzhen), Longgang, Shenzhen, Guangdong, 518172, P.R. China.ORCID 0000-0003-0728-1178
Xiaolin XieKey Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, P.R. China.
Ben Zhong TangDepartment of Chemistry, the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, P.R. China.ORCID 0000-0002-0293-964X

Funding

Guangdong Basic Research Center of Excellence for Aggregate Science, the Science, Technology, and Innovation Commission of Shenzhen Municipality JCYJ20220530143805012Guangdong Basic Research Center of Excellence for Aggregate Science, the Science, Technology, and Innovation Commission of Shenzhen Municipality JCYJ20241202152659001Guangdong Basic Research Center of Excellence for Aggregate Science, the Science, Technology, and Innovation Commission of Shenzhen Municipality KQTD20210811090142053Guangdong Provincial Program 2023QN10C140Innovation and Technology Commission of Hong Kong ITC-CNERC14SC01National Natural Science Foundation of China 51973072National Natural Science Foundation of China 52103258National Natural Science Foundation of China 52303382National Natural Science Foundation of China 52333007Shenzhen Science and Technology Program 2024SC0019
6 · The paper itself

Abstract

Biomacromolecules such as DNA, proteins, and polysaccharides possess unique helical structures that are closely related to their biological functions involving recognition, catalysis, replication, and genetic information storage. From a biomimetic perspective, artificial foldamers are the ideal systems to model and study the structure-property relationship of biomacromolecules. Herein, we report a facile, rapid, and cost-effective method to directly visualize and monitor the solvent-driven helix inversion in a water-soluble poly(m-phenylene ethynylene)-based foldamer with the aid of a tetraphenylethene-functionalized hemicyanine dye. By adjusting the solvent environment, the foldamer transitions from an M-helix to a P-helix, accompanied by a change in the dye's binding mode from groove to surface. This transition alters the degree of restriction and microenvironment polarity, resulting in a visible emission color change from yellow to red, signaling the helix inversion. The present investigation offers a powerful tool for understanding conformational transitions in biomacromolecules and offers insights into the dynamic behavior of helical structures.

Indexed as

Biomimetic MaterialsPolymersFluorescencePolymerspoly(phenylene ethynylene)Artificial foldamerFluorescence visualizationHelix inversionIntramolecular charge transfer

Identifiers

PMID41159756
PMCPMC12723458

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.