Evidence map›Paper›PMID 41159753›Full record

ArticleJournal of virology2025

Differential expression of viral entry protein neuropilin 1 (NRP1) and neuropilin 2 (NRP2) in fatal COVID-19.

A Dette, F Moers, T Mayr, S V Stillfried, M Bernhardt, S Förster, C Werlein, M Ackermann, M H Muders, G Kristiansen and 2 more

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. The effects of SARS-CoV-2 on bone homeostasis.Frontiers in endocrinology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

A DetteInstitute of Pathology, University Hospital Bonn, Bonn, Germany.ORCID 0009-0009-5318-832X
F MoersInstitute of Pathology, University Hospital Bonn, Bonn, Germany.
T MayrInstitute of Pathology, University Hospital Bonn, Bonn, Germany.ORCID 0000-0002-2900-1782
S V StillfriedInstitute of Pathology, RWTH Aachen University Hospital, Aachen, Germany.
M BernhardtInstitute of Pathology, University Hospital Bonn, Bonn, Germany.
S FörsterInstitute of Pathology, University Hospital Bonn, Bonn, Germany.
C WerleinInstitute of Pathology, Hannover Medical School, Hanover, Germany.
M AckermannInstitute of Pathology, RWTH Aachen University Hospital, Aachen, Germany.
M H MudersInstitute of Pathology, University Hospital Bonn, Bonn, Germany.
G KristiansenInstitute of Pathology, University Hospital Bonn, Bonn, Germany.
P BoorInstitute of Pathology, RWTH Aachen University Hospital, Aachen, Germany.
I GütgemannInstitute of Pathology, University Hospital Bonn, Bonn, Germany.ORCID 0000-0002-2609-3095

Funding

aTyrBONFOR O-115.0074National Autopsy Network 01KX2524
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is associated with hyperinflammation, endothelialitis, hypoxemia, and hypercoagulation, contributing to thrombosis in acute severe and long COVID. While ACE2 is the primary severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor, its low expression in certain infected cell types suggests alternative co-receptors. Neuropilins (NRP1 and NRP2), widely expressed, have been proposed as co-factors for viral entry. We analyzed NRP1 and NRP2 expression in autopsy tissues from heart, lung, and hematolymphoid organs using immunohistochemistry (

Indexed as

COVID-19Neuropilin-1Neuropilin-2SARS-CoV-2AgedAngiotensin-Converting Enzyme 2Endothelial CellsFemaleHumansLungMaleMiddle AgedMyocardiumSpike Glycoprotein, CoronavirusVirus InternalizationACE2 protein, humanAngiotensin-Converting Enzyme 2Neuropilin-1Neuropilin-2neuropilin-2, humanNRP1 protein, humanSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2CODEXCOVID-19neuropilinsNRP1NRP2PASCSARS-CoV-2scRNAspike protein

Identifiers

PMID41159753
PMCPMC12645918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.