Evidence map›Paper›PMID 41159688›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Intact Mass Profiling Reveals Phospho-Proteoforms of the Catenins (85-110 kDa) Regulated by Actomyosin Contractility.

Che-Fan Huang, Taojunfeng Su, Annette S Flozak, Cara J Gottardi, Neil L Kelleher

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Che-Fan HuangDepartments of Chemistry, Molecular Biosciences, and Proteomics Center of Excellence, Northwestern University, 2170 Campus Dr. Silverman B550, Evanston, Illinois, 60208, USA.ORCID 0000-0002-5799-1533
Taojunfeng SuDepartments of Chemistry, Molecular Biosciences, and Proteomics Center of Excellence, Northwestern University, 2170 Campus Dr. Silverman B550, Evanston, Illinois, 60208, USA.
Annette S FlozakDepartments of Medicine (Pulmonary and Critical Care), and Cell & Developmental Biology, Feinberg School of Medicine, Northwestern University, 303 E. Superior St. Simpson-Querrey 525, Chicago, Illinois, 60611, USA.
Cara J GottardiDepartments of Medicine (Pulmonary and Critical Care), and Cell & Developmental Biology, Feinberg School of Medicine, Northwestern University, 303 E. Superior St. Simpson-Querrey 525, Chicago, Illinois, 60611, USA.ORCID 0000-0003-0912-7617
Neil L KelleherDepartments of Chemistry, Molecular Biosciences, and Proteomics Center of Excellence, Northwestern University, 2170 Campus Dr. Silverman B550, Evanston, Illinois, 60208, USA.ORCID 0000-0002-8815-3372

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
National Center for Translational and Developmental ProteomicsRM1GM156535 · NIGMS · NORTHWESTERN UNIVERSITY · PI NEIL L KELLEHER · 2025 to 2026
$3.4M
Alveolar epithelial stress-induced polyploidization in lung injury and repairR01HL163611 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOTTARDI, CARA J · 2022 to 2025
$2.5M
Cadherin-catenin regulation in dividing epithelial cellsR01GM129312 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOTTARDI, CARA J · 2018 to 2021
$1.5M
Acquisition of a Thermo Fisher Scientific Q Exactive UHMR mass spectrometerS10OD025194 · OD · NORTHWESTERN UNIVERSITY · PI COMPTON, PHILIP DANIEL · 2018 to 2018
$795k
National Institutes of Health Office of Director S10OD025194NCI NIH HHS P30 CA060553NHLBI NIH HHS R01 HL163611NHLBI NIH HHS R01HL163611NIGMS NIH HHS R01 GM129312NIGMS NIH HHS R01GM129312NIGMS NIH HHS RM1 GM156535NIGMS NIH HHS RM1GM156535NIH HHS S10 OD025194
6 · The paper itself

Abstract

A central challenge in top-down proteomics (TDP) is the characterization of large proteoforms (>70 kDa) due to their high spectral complexity in mass spectrometers. Here, we advance individual ion mass spectrometry (I

Indexed as

ActomyosinCateninsHEK293 CellsHumansMass SpectrometryPhosphorylationProteomicsActomyosinCateninsCateninsMass spectrometryPhosphorylationProteoformTop‐down proteomics

Identifiers

PMID41159688
PMCPMC12723464

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.