Evidence map›Paper›PMID 41159649›Full record

ArticleAustralian endodontic journal : the journal of the Australian Society of Endodontology Inc2026

Cyotoxicity of Etidronate as an Endodontic Chelator Against Periodontal Ligament Fibroblast.

Bruno Vila Nova de Almeida, Patrícia de Almeida Rodrigues, Geovanni Pereira Mitre, Maria Sueli da Silva Kataoka, João de Jesus Viana Pinheiro, Talita Tartari, Oscar Faciola Pessoa

Abstract read
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In one paragraph

Article in Australian endodontic journal : the journal of the Australian Society of Endodontology Inc, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bruno Vila Nova de AlmeidaDepartment of Endodontic, Dental School, Federal University of Para, Belem, Pará, Brazil.ORCID https://orcid.org/0000-0003-3898-3922
Patrícia de Almeida RodriguesDepartment of Endodontic, Dental School, Federal University of Para, Belem, Pará, Brazil.ORCID https://orcid.org/0000-0003-3589-0771
Geovanni Pereira MitreDepartment of Pathology, Dental School, Federal University of Para, Belem, Pará, Brazil.ORCID https://orcid.org/0000-0001-7011-0457
Maria Sueli da Silva KataokaDepartment of Pathology, Dental School, Federal University of Para, Belem, Pará, Brazil.ORCID https://orcid.org/0000-0001-9650-1034
João de Jesus Viana PinheiroDepartment of Pathology, Dental School, Federal University of Para, Belem, Pará, Brazil.ORCID https://orcid.org/0000-0002-6914-6441
Talita TartariDepartment of Restorative Dentistry, Piracicaba School of Dentistry, State University of Campinas, Piracicaba, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-4372-0158
Oscar Faciola PessoaDepartment of Endodontic, Dental School, Federal University of Para, Belem, Pará, Brazil.ORCID https://orcid.org/0000-0002-4386-4613

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Etidronic acid (HEBP) causes fewer alterations in dentine and can be used mixed with sodium hypochlorite during root canal preparation. This study investigated the cytotoxicity effects of the HEDP and EDTA on human periodontal ligament fibroblast cells. Primary culture was established from human periodontal ligament tissue of one donor and was characterised by immunofluorescence and real-time quantitative polymerase chain reaction. The half-maximal inhibitory concentration (IC

Indexed as

Chelating AgentsEtidronic AcidFibroblastsPeriodontal LigamentRoot Canal IrrigantsCells, CulturedCell SurvivalEdetic AcidHumansReal-Time Polymerase Chain ReactionChelating AgentsEdetic AcidEtidronic AcidRoot Canal Irrigantschelating agentscytotoxicityEDTAetidronateperiodontal ligament fibroblasts

Identifiers

PMID41159649
PMCPMC13051004

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.