Evidence map›Paper›PMID 41159492›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Hippocampal Chandelier Cells Modulate Seizure Susceptibility and Severity.

Yang Li, Jifeng Tian, Jiafan Wei, Qianyun Wang, Jiaxu Ge, Jianguang Ni, Jiangteng Lu, Yilin Tai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Hippocampal Chandelier Cells Modulate Seizure Susceptibility and Severity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yang LiState Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
Jifeng TianState Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
Jiafan WeiState Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
Qianyun WangState Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
Jiaxu GeState Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
Jianguang NiState Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
Jiangteng LuSongjiang Hospital and Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Yilin TaiState Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, and the Institutes of Brain Science, Fudan University, Shanghai, 200032, China.ORCID https://orcid.org/0009-0005-7440-0263

Funding

China Postdoctoral Science Foundation 2021M700838National Key R&D program of China 2024YFF1206500National Natural Science Foundation of China 32100795National Natural Science Foundation of China 32371006National Natural Science Foundation of China 32371073National Natural Science Foundation of China 82071450National Natural Science Foundation of China T2394531Shanghai Pilot Program for Basic Research-Fudan University 21TQ1400100(25TQ002)
6 · The paper itself

Abstract

The axon initial segment (AIS), serving as the site for initiating action potentials (APs), is a key target for efficient regulation of neuronal activity. In mammals, chandelier cells (ChCs) represent a distinct subtype of GABAergic interneurons that selectively target the AIS of projection neurons (PNs). This strategic property endows them with the potential to effectively control the firing of PNs. They respond to diverse physiological stimuli and undergo homeostatic plasticity during network hyperactivity. However, their response in pathological states, such as epileptic seizures, remains unclear. In this study, we observed an increase in the ChC Ca

Indexed as

GABAergic NeuronsHippocampusInterneuronsSeizuresAction PotentialsAnimalsDisease Models, AnimalDisease SusceptibilityKainic AcidMaleMiceKainic Acidaxon initial segmentchandelier cellsseizure

Identifiers

PMID41159492
PMCPMC12822456

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.