Evidence map›Paper›PMID 41159490›Full record

ArticleNanomedicine (London, England)2025

Quantitative proteomic and phenotypic responses of urinary pathogens to CuO/Cu₂O nanoparticles.

Kidon Sung, Miseon Park, Ohgew Kweon, Alena Savenka, Angel Paredes, Saeed Khan, Seonggi Min, Steven Foley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kidon SungDivision of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA.ORCID 0000-0002-7926-6156
Miseon ParkDivision of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA.
Ohgew KweonDivision of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA.
Alena SavenkaNanotechnology Core Facility, Office of Scientific Coordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA.
Angel ParedesNanotechnology Core Facility, Office of Scientific Coordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA.
Saeed KhanDivision of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA.
Seonggi MinDivision of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA.
Steven FoleyDivision of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA.

Funding

U.S. Food and Drug Administration
6 · The paper itself

Abstract

aimsTo evaluate the antibacterial efficacy of pulsed laser ablation-generated copper oxide (CuO/Cu₂O) nanoparticles (NPs) against urinary pathogens and to elucidate molecular stress responses through proteomic profiling.

methods

resultsCuO/Cu₂O NPs significantly reduced viability, with

conclusionsCuO/Cu₂O NPs exert rapid antibacterial activity via oxidative stress, membrane disruption, and metabolic reprogramming. Distinct proteomic adaptations explain species differences in susceptibility and highlight copper nanoparticles as promising antimicrobial candidates.

Indexed as

Anti-Bacterial AgentsCopperMetal NanoparticlesNanoparticlesUrinary Tract InfectionsEnterococcus faecalisEscherichia coliHumansProteomicsProteus mirabilisPseudomonas aeruginosaAnti-Bacterial AgentsCoppercupric oxidecuprous oxideCopper nanoparticlesEnterococcus faecalisproteomeProteus mirabilisurinary pathogens

Identifiers

PMID41159490
PMCPMC12710891

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.