Evidence map›Paper›PMID 41159480›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Chloroplast Fibrillin-Mediated α-Tocopherol Biosynthesis Impaired by a Virus to Enhance Infection and to Improve Drought Tolerance.

Sijia Liu, Xuedong Liu, Qin Yan, Xi Chen, Lianyi Zang, Jingang Hu, Xiaoping Zhu, Zaifeng Fan, Tao Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sijia LiuState Key Laboratory of Agricultural and Forestry Biosecurity, Key Laboratory of Surveillance and Management for Plant Quarantine Pests, Ministry of Agriculture and Rural Affairs, P. R. China, Department of Plant Pathology, China Agricultural University, Beijing, 100193, China.
Xuedong LiuState Key Laboratory of Agricultural and Forestry Biosecurity, Key Laboratory of Surveillance and Management for Plant Quarantine Pests, Ministry of Agriculture and Rural Affairs, P. R. China, Department of Plant Pathology, China Agricultural University, Beijing, 100193, China.
Qin YanState Key Laboratory of Agricultural and Forestry Biosecurity, Key Laboratory of Surveillance and Management for Plant Quarantine Pests, Ministry of Agriculture and Rural Affairs, P. R. China, Department of Plant Pathology, China Agricultural University, Beijing, 100193, China.
Xi ChenState Key Laboratory of Agricultural and Forestry Biosecurity, Key Laboratory of Surveillance and Management for Plant Quarantine Pests, Ministry of Agriculture and Rural Affairs, P. R. China, Department of Plant Pathology, China Agricultural University, Beijing, 100193, China.
Lianyi ZangState Key Laboratory of Agricultural and Forestry Biosecurity, Key Laboratory of Surveillance and Management for Plant Quarantine Pests, Ministry of Agriculture and Rural Affairs, P. R. China, Department of Plant Pathology, China Agricultural University, Beijing, 100193, China.
Jingang HuDepartment of Tomato Breeding, Zhengzhou Vegetable Research Institute, Zhengzhou, 450015, China.
Xiaoping ZhuDepartment of Plant Pathology, College of Plant Protection, Shandong Agricultural University, Taian, 271018, China.
Zaifeng FanState Key Laboratory of Agricultural and Forestry Biosecurity, Key Laboratory of Surveillance and Management for Plant Quarantine Pests, Ministry of Agriculture and Rural Affairs, P. R. China, Department of Plant Pathology, China Agricultural University, Beijing, 100193, China.
Tao ZhouState Key Laboratory of Agricultural and Forestry Biosecurity, Key Laboratory of Surveillance and Management for Plant Quarantine Pests, Ministry of Agriculture and Rural Affairs, P. R. China, Department of Plant Pathology, China Agricultural University, Beijing, 100193, China.ORCID https://orcid.org/0000-0001-7702-8472

Funding

Basic and Applied Basic Research Foundation of Guangdong 2023A1515110407Beijing Innovation Consortium of Agriculture Research System BAIC01-2018-2023Beijing Innovation Consortium of Agriculture Research System BAIC12-2024-2025National Key R&D Program of China 2022YFD1401200National Natural Science Foundation of China 32302317National Natural Science Foundation of China 32402310Shandong Provincial Natural Science Foundation ZR2017CM058Shenzhen Science and Technology Program RCBS20231211090625044
6 · The paper itself

Abstract

Plastoglobules (PGs), the lipid droplets mainly within chloroplasts, are crucial for plant redox homeostasis and environmental adaptation. However, the regulation of PG under stress remains elusive. This study uncovers that PGs are targeted by the p22 protein encoded by an emerging virus-tomato chlorosis virus (ToCV), leading to impaired α-tocopherol biosynthesis, thereby facilitating viral infection and improving drought resistance. Specially, ToCV-encoded p22 protein co-opts the PG structural protein fibrillin (FBN) to access PG, where it impairs α-tocopherol biosynthesis via disturbing the interaction between FBN1.1 and tocopherol cyclase (VTE1). Alpha-tocopherol is required for both preventing lipid peroxidation in the thylakoid membrane and suppressing ToCV infection. Infection of ToCV or transgenic expression of p22 protein inhibits α-tocopherol biosynthesis, resulting in chloroplast oxidative stress, which may contribute to the accumulation of 3'-phosphoadenosine 5'-phosphate (PAP), a retrograde signal from chloroplasts to the nucleus that triggers drought tolerance. Taken together, FBN1.1 modulates plant-virus-drought interaction via regulating the function of PG.

Indexed as

alpha-TocopherolChloroplastsFibrillinsDrought ResistanceDroughtsOxidative StressPlant Diseasesalpha-TocopherolFibrillinsantioxidantsdrought stressfibrillin (FBN)retrograde signaltomato chlorosis virus

Identifiers

PMID41159480
PMCPMC12806216

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.