Evidence map›Paper›PMID 41159443›Full record

ArticleeLife2025

Axonal injury signaling is restrained by a spared synaptic branch.

Laura J Smithson, Juliana L Zang, Lucas Junginger, Thomas J Waller, Lauren Reilly-Jankowiak, Sophia A Khan, Ye Li, Dawen Cai, Catherine A Collins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laura J SmithsonDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.ORCID https://orcid.org/0000-0003-1529-3005
Juliana L ZangDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.ORCID https://orcid.org/0000-0002-5738-8355
Lucas JungingerDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.
Thomas J WallerDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.ORCID https://orcid.org/0000-0002-3098-9070
Lauren Reilly-JankowiakDepartment of Neurosciences, Case Western Reserve University, Cleveland, United States.ORCID https://orcid.org/0000-0002-7496-6866
Sophia A KhanDepartment of Neurosciences, Case Western Reserve University, Cleveland, United States.ORCID https://orcid.org/0009-0004-1416-5022
Ye LiDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, United States.ORCID https://orcid.org/0000-0002-8647-384X
Dawen CaiDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, United States.ORCID https://orcid.org/0000-0003-4471-2061
Catherine A CollinsDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.ORCID https://orcid.org/0000-0002-1608-6692

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Regenerative and Degenerative Responses to Axonal InjuryR01NS069844 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CADIGAN, KENNETH M, COLLINS, CATHERINE A · 2010 to 2024
$5.0M
Cellular Biotechnology Training Program (CBTP) - Years 31-35T32GM145304 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Guizhi Zhu · 2022 to 2026
$2.6M
Regenerative and degenerative responses to axonal injuryR56NS069844 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, CATHERINE A · 2020 to 2020
$546k
NIGMS NIH HHS T32 GM145304NIH HHS NS069844NIH HHS P40 OD018537NINDS NIH HHS R01 NS069844NINDS NIH HHS R56 NS069844
6 · The paper itself

Abstract

The intrinsic ability of injured neurons to degenerate and regenerate their axons facilitates nervous system repair; however, this ability is not engaged in all neurons and injury locations. Here, we investigate the regulation of a conserved axonal injury response pathway with respect to the location of damage in branched motoneuron (MN) axons in

Indexed as

AxonsDrosophila melanogasterDrosophila ProteinsMAP Kinase Kinase KinasesMotor NeuronsSignal TransductionSynapsesAnimalsDrosophilaLarvaNerve Tissue ProteinsDrosophila ProteinsHIW protein, DrosophilaMAP Kinase Kinase Kinasesmitogen-activated protein kinase kinase kinase 12Nerve Tissue Proteinswnd protein, Drosophilaaxonal degenerationaxonal injury signalingaxonal regenerationD. melanogasterneurosciencespared synapsestructural plasticity

Identifiers

PMID41159443
PMCPMC12571483

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.