ArticleArchives of Iranian medicine2025
High-Sensitivity C-Reactive Protein and its Association with Diabetic Retinopathy: A Cross-sectional Study.
Article in Archives of Iranian medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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5 authors.
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Abstract
backgroundChronic low-grade inflammation is implicated in diabetic microvascular complications, but the relationship between circulating high-sensitivity C-reactive protein (hs-CRP) and diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) remains incompletely defined. We evaluated whether plasma hs-CRP levels are independently associated with DR presence and severity in a cohort of T2DM patients.
methodsIn this analytical cross-sectional study, 149 T2DM patients referring to endocrinology and ophthalmology clinics at Babol University of Medical Sciences (April 2022-June 2023) were categorized into no DR (n=50), non-proliferative DR (NPDR; n=49), and proliferative DR (PDR; n=50) groups. Comprehensive ophthalmic examination classified DR stage. We measured hs-CRP (low: 0-1 mg/L, moderate: 1-3 mg/mL, high:>3 mg/mL), HbA1c, fasting blood sugar (FBS), and total cholesterol in fasting blood samples. Statistical analysis was performed with SPSS v.22.
resultsMean hs-CRP concentrations rose progressively with DR severity: 2.71±1.14 mg/L (no DR), 4.89±5.31 mg/L (NPDR), and 10.60±9.24 mg/L (PDR;
conclusionHigh hs-CRP levels correlate with DR severity in T2DM, highlighting inflammation's role and potential for early detection strategies.
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