Factors Associated With the Risk of Neuropathic Pain One Year After Total Knee Arthroplasty and the Protective Role of Local Infiltration Analgesia: A Registry-Based Prospective Cohort Study.

Hermes H Miozzari, Alice Bonnefoy-Mazure, Nicolas Silvestrini, Christophe Barea, Didier Hannouche, Anne Lübbeke

Abstract read

In one paragraph

Article in ACR open rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Refractory Chronic Knee Pain After Total Knee Replacement Successfully Treated With L4 Dorsal Root Ganglion Pulsed Radiofrequency.Cureus · 2026
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hermes H MiozzariDivision of Orthopedic Surgery and Musculoskeletal Trauma Care, Geneva University Hospitals, University of Geneva, Faculty of Medicine, Geneva, Switzerland.

Alice Bonnefoy-MazureDivision of Orthopedic Surgery and Musculoskeletal Trauma Care, Geneva University Hospitals, University of Geneva, Faculty of Medicine and Willy Taillard Laboratory of Kinesiology, Geneva University Hospitals, University of Geneva, Faculty of Medicine, Geneva, Switzerland.

Nicolas SilvestriniDivision of Orthopedic Surgery and Musculoskeletal Trauma Care, Geneva University Hospitals, University of Geneva, Faculty of Medicine and Clinical Research Center and Division of Clinical-Epidemiology, Department of Health and Community Medicine, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.

Christophe BareaDivision of Orthopedic Surgery and Musculoskeletal Trauma Care, Geneva University Hospitals, University of Geneva, Faculty of Medicine, Geneva, Switzerland.

Didier HannoucheDivision of Orthopedic Surgery and Musculoskeletal Trauma Care, Geneva University Hospitals, University of Geneva, Faculty of Medicine, Geneva, Switzerland.

Anne LübbekeDivision of Orthopedic Surgery and Musculoskeletal Trauma Care, Geneva University Hospitals, University of Geneva, Faculty of Medicine, Geneva, Switzerland, and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify predictors of reduced risk for neuropathic pain (NP) one year after total knee arthroplasty (TKA) among patients who did not report NP before surgery.

methodsWe included primary TKAs performed between January 1, 2014, and June 30, 2022. NP was defined as Douleur Neuropathique en 4 Questions scores ≥4 before and one year after TKA. We selected patients without NP before surgery and ran simple log-binomial regressions and a multiple log-binomial regression on the presence or absence of NP at one year after surgery. We included predictive variables associated with patient characteristics (sex, age at surgery, body mass index [BMI], smoking status, diabetes, medication, and short-form 12-question [SF-12] mental scores) and operative variables (patella resurfacing, type of anesthesia, glucocorticoids, and local infiltration analgesia [LIA]).

resultsA total of 889 patients were included for initial analysis, with 636 included in the log-binomial regression. The incidence of NP at one year among the latter was 8.6% (55 of 636). LIA had a strong protective effect with an adjusted risk ratio (RR) of 0.45 (95% confidence interval [CI] 0.26-0.77). LIA led to an NP risk reduction of 6.1% (95% CI 1.4-10.7; 12.2% of NP without infiltration and 6.1% with). The other protective factors identified were higher SF-12 mental scores (adjusted RR 0.97; 95% CI 0.95-1.00), older age (adjusted RR per decade 0.78; 95% CI 0.59-1.03), and BMI <35 (adjusted RR 0.60; 95% CI 0.33-1.09).

conclusionsOur study identified factors associated with reduced risk of NP one year after TKA among patients without preoperative NP. The use of LIA was newly identified as being associated with a lower likelihood of NP after surgery.

Identifiers

PMID41159305

DOI10.1002/acr2.70107

PMCPMC12569525

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