Evidence map›Paper›PMID 41159296›Full record

ArticleMovement disorders clinical practice2026

Clinical Outcome Assessments in Parkinson's Disease: A Scoping Review of Current Rating Scales and Future Needs.

Evita Papathoma, Panagiota Tsitsi, Nirosen Vijiaratnam, Camila Aquino, Stephen R Duma, Norbert Kovacs, Kigocha Lameck Okeng'o, Aparna Wagle Shukla, Roongroj Bhidayasiri, Tiago A Mestre and 5 more

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Evita PapathomaDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Panagiota TsitsiDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0003-3790-0398
Nirosen VijiaratnamDepartment of Clinical and Movement Neuroscience, University College London Queen Square Institute of Neurology, London, UK.ORCID https://orcid.org/0000-0002-9671-0212
Camila AquinoHotchkiss Brain Institute, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Stephen R DumaDepartment of Neurology, St George Hospital, Sydney, Australia.ORCID https://orcid.org/0000-0002-6160-4807
Norbert KovacsDepartment of Neurology, Medical School, University of Pécs, Baranya, Hungary.
Kigocha Lameck Okeng'oMuhimbili National Hospital, Dar es Salaam, Tanzania.
Aparna Wagle ShuklaFixel Insititute for Neurological Sciences, University of Florida, Gainesville, Florida, USA.
Roongroj BhidayasiriChulalongkorn Centre of Excellence for Parkinson's Disease & Related Disorders, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.ORCID https://orcid.org/0000-0002-6901-2064
Tiago A MestreParkinson's Disease and Movement Disorders Clinic, Division of Neurology, Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa Brain and Mind Institute, Ottawa, ON, Canada.
Alvaro Sanchez FerroMovement Disorders Unit, Neurology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
Alberto J EspayJames J. and Joan A. Gardner Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA.
Michelle H S TosinDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Matej SkorvanekDepartment of Neurology, University of Pavol Jozef Safarik in Kosice, Kosice, Slovakia.ORCID https://orcid.org/0000-0001-5497-8715
Ioanna MarkakiDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0003-3328-5746

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClinical outcome assessments (COAs) are essential for evaluating symptom severity, treatment response, and disease progression in Parkinson's disease (PD). As clinical knowledge evolves, it is necessary to revisit the recommendation status on the COAs to ensure their continued relevance and validity.

objectivesTo provide an updated overview of existing MDS-recommended COAs in PD and to identify specific constructs requiring revision or further validation to inform current clinical practice and research.

methodsThe Scientific Evaluation Committee of the Movement Disorder Society COA program commissioned a position paper on the current state of COAs' recommendations. A panel of experts conducted a two-step review: first, extracting data from previous MDS publications of rating scales on COAs appraisals using a standardized template; second, conducting a scoping review up to April 2025 to identify new COAs or updated validation data on motor and non-motor constructs in PD. All study designs were considered.

resultsOf the 19 PD constructs identified, anxiety, apathy, anhedonia, dysautonomia, and pain had significant developments, including new COA development and further validation, making them priorities for revision. Recent reviews show that constructs like medication adherence and psychosis were sufficiently addressed.

conclusionsThis review identifies key symptom areas where COA critique and recommendations need to be updated to reflect advances in the field and improve assessment accuracy in clinical and research settings.

Indexed as

Outcome Assessment, Health CareParkinson DiseaseHumansSeverity of Illness Indexmotor symptomsnon‐motor symptomsParkinson's diseasepatient outcome assessmentpsychometrics

Identifiers

PMID41159296
PMCPMC13172760

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.