ArticleJournal of research in health sciences2025
Sociodemographic and Clinical Factors Associated with Tuberculosis Mortality in Hamadan Province, Iran.
Article in Journal of research in health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTuberculosis (TB) remains a global health concern with high mortality despite treatment options. Understanding the underlying risk factors for TB mortality is essential for guiding effective control strategies. This study examined sociodemographic and clinical factors related to TB mortality in Hamadan province, Iran, to inform control strategies.
methodsThis study evaluated data (March 2011-March 2022) obtained from a provincial TB surveillance database, encompassing smear-positive pulmonary TB (SPT), smear-negative pulmonary TB (SNT), and extrapulmonary TB (EPT) patients. Demographic and clinical characteristics were investigated, and the death rate for each group was calculated by dividing the number of TB-related deaths by the total number of diagnosed TB cases for that group during the study period. Logistic regression was applied to computed unadjusted and adjusted odds ratios (ORs) with a 95% confidence interval for the death rate using Stata 17 (
resultsAmong the 942 patients included in the study, 49%, 21%, and 30% were diagnosed with SPT, SNT, and EPT, respectively. The risk of mortality was the highest among SPT patients, with EPT cases showing significantly lower odds of death (OR: 0.38,
conclusionTargeted interventions focusing on early diagnosis, HIV management, and care for high-risk groups (e.g., elderly) are essential to reduce TB mortality in Hamadan province. However, the findings should be interpreted with caution due to limitations, such as reliance on retrospective registry data, potential information bias, and missing data, particularly regarding HIV status.
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