ArticleFrontiers in neurology2025
Efficacy of repetitive transcranial magnetic stimulation for consciousness recovery in children with disorders of consciousness following traumatic brain injury.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Rehabilitation in Pediatric Patients with Acute and Subacute Acquired Brain Injury: A Scoping Review on Non-Pharmacological Interventions.Journal of clinical medicine · 2026Review
- Neuromodulation for pediatric disorders of consciousness: bridging the gap between adult evidence and developmental reality.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate the efficacy of 5 Hz repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (left DLPFC) for consciousness recovery in children with disorders of consciousness (DOC) following traumatic brain injury (TBI). Methods: This randomized controlled trial included 98 pediatric patients aged ≥2 years with DOC after TBI, admitted to Kunming Children's Hospital from January 2023 to July 2025. Patients were randomly divided into an experimental group ( Results: After 3 weeks of intervention, the experimental group demonstrated statistically significant improvements compared to both baseline status and the control group ( Conclusion: This study provided the first clinical evidence that the combined application of 5 Hz rTMS targeting the left DLPFC is a safe and effective intervention for promoting the recovery of consciousness in children with DOC following TBI. Significant improvements in behavioral scales (CRS-R, GCS) and reduced levels of the neurological injury marker (serum NSE) suggest that this protocol exerts dual effects of promoting arousal and neuroprotection. This novel treatment approach, designed based on the characteristics of pediatric neurological development, offers a promising non-invasive neuromodulation strategy for this challenging patient population, filling a critical evidence gap in this field.
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Registered trials
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