ReviewMedComm2025
Intracerebral Hemorrhage: Advances, Knowledge Gaps, and Future Directions.
Review in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mechanisms of exercise-based rehabilitation following intracerebral hemorrhage: insights from preclinical evidence.Frontiers in pharmacology · 2026Pooled it
- Admission low-density lipoprotein cholesterol and early haematoma expansion after spontaneous intracerebral haemorrhage.Annals of medicine · 2026Article
- Cerebrospinal Fluid Hemopexin as a Candidate Biomarker for Secondary Sepsis and In-Hospital Outcome After Spontaneous Intracerebral Hemorrhage: An Exploratory Translational Proteomics Study.Neurocritical care · 2026Article
- Artificial Intelligence in Intracerebral Hemorrhage: Current Applications and Future Perspectives.Journal of clinical medicine · 2026Review
- Impact of Invasive Intracranial Pressure Monitoring on Outcomes in Older Adults with Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis.Neurocritical care · 2026Article
- Steric hindrance-mediated extracellular vesicle size fractionation for rapid prehospital diagnosis of intracerebral hemorrhage.Nature communications · 2026Article
- Prognostic Significance of Triglyceride Glucose Index in Intracerebral Hemorrhage.Medical sciences (Basel, Switzerland) · 2026Article
- Risk factors and development of a prediction model for hematoma expansion in elderly patients with spontaneous intracerebral hemorrhage.Frontiers in aging neuroscience · 2026Article
- Recent research progress and future directions of intracerebral hemorrhage.Frontiers in immunology · 2026Review
- Regulatory T cells in intracerebral hemorrhage: mechanisms of immunomodulation and therapeutic potential.Frontiers in immunology · 2026Review
- Mitochondrial dysfunction in intracerebral hemorrhage: molecular mechanisms and pathological consequences.Frontiers in cellular neuroscience · 2026Review
- A pilot study of helicopter emergency medical services in the Zhoushan Archipelago: clinical experience and operational insights from 18 cases.Frontiers in public health · 2026Article
- Systemic inflammatory biomarkers CAR and IL-6: correlation with neurological deficit and short-term prognosis of intracerebral hemorrhage.Frontiers in neurology · 2026Article
- Review
- Association of nadir serum albumin during hospitalization with mortality in ICU patients with spontaneous intracerebral hemorrhage.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute spontaneous intracerebral hemorrhage (ICH) remains a severe and challenging cerebrovascular condition, associated with high rates of morbidity and mortality. The pathophysiology of injury following ICH involves mass effect, increased intracranial pressure, hematoma expansion, and toxicity from blood-breakdown products. Over the past decade, substantial progress has been made in risk stratification, therapeutic strategies, and outcome prognostication. Although case-fatality rates have declined with advances in neuroimaging, acute care, and surgical techniques, functional outcomes remain poor, with little improvement. Several trials have investigated the optimal medical and surgical treatments for ICH, but none have shown significant improvements in outcomes or survival. This review aims to provide a comprehensive overview of ICH, including its epidemiology, associated costs, pathophysiological mechanisms, and management approaches. Herein, we explored recent advancements in neuroimaging techniques and their roles in diagnosing ICH and predicting patient outcomes. Additionally, we assessed the impact of prehospital and in-hospital management practices, such as pharmacological and surgical interventions, and discussed the implications of delays before final treatment. By summarizing current research and evidence-based practices, this review aims to highlight established and emerging strategies for improving outcomes for patients with ICH and identify areas for future research and development in the field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.