Evidence map›Paper›PMID 41159135›Full record

ArticleJournal of molecular and cellular cardiology plus2025

Quantification of morphological, functional, and biochemical features of H9c2 rat cardiomyoblast retinoic acid differentiation.

Nicole S York, Joel E Rivera, Mohammadreza Rahmani Manesh, K'sana Wood Lynes-Ford, Rory Smith, Leigh E Wicki-Stordeur, Laura T Arbour, Leigh Anne Swayne

Abstract read
In one paragraph

Article in Journal of molecular and cellular cardiology plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicole S YorkSchool of Medical Sciences, Faculty of Health, University of Victoria, Victoria, British Columbia, Canada.
Joel E RiveraSchool of Medical Sciences, Faculty of Health, University of Victoria, Victoria, British Columbia, Canada.
Mohammadreza Rahmani ManeshSchool of Medical Sciences, Faculty of Health, University of Victoria, Victoria, British Columbia, Canada.
K'sana Wood Lynes-FordSchool of Medical Sciences, Faculty of Health, University of Victoria, Victoria, British Columbia, Canada.
Rory SmithSchool of Medical Sciences, Faculty of Health, University of Victoria, Victoria, British Columbia, Canada.
Leigh E Wicki-StordeurSchool of Medical Sciences, Faculty of Health, University of Victoria, Victoria, British Columbia, Canada.
Laura T ArbourSchool of Medical Sciences, Faculty of Health, University of Victoria, Victoria, British Columbia, Canada.
Leigh Anne SwayneSchool of Medical Sciences, Faculty of Health, University of Victoria, Victoria, British Columbia, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell culture models enable advancement in our understanding of heart development and heart disease. The H9c2 rat ventricular cardiomyoblast cell line can be differentiated with retinoic acid and low serum, leading to morphological, molecular, and functional changes that partially resemble aspects of cardiomyoblast-to-cardiomyocyte differentiation. However, morphological, functional, and biochemical changes are rarely investigated in parallel, thereby limiting fulsome understanding of how these processes are interlinked, and to what extent these model cardiomyoblasts can be differentiated. To provide a parallel analysis as a resource for future studies, we therefore characterized H9c2 cell morphology, Ca

Indexed as

DifferentiationH9c2MorphologyRetinoic acidSpontaneous Ca2+ transients

Identifiers

PMID41159135
PMCPMC12557580

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.