Evidence map›Paper›PMID 41159064›Full record

ArticleFrontiers in toxicology2025

Refining the safety assessment of newly expressed proteins in GMOs.

Elena Sánchez-Brunete, Arianna Ferrari, F Javier Moreno, Tilemachos Goumperis, Michele Ardizzone, Reinhilde Schoonjans, Ian Dewhurst, Ivan Dimitrov, Michelle M Epstein, Frits Koning and 2 more

Abstract read
In one paragraph

Article in Frontiers in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Elena Sánchez-Brunete *European Food Safety Authority (EFSA), Parma, Italy.
Arianna Ferrari *European Food Safety Authority (EFSA), Parma, Italy.
F Javier MorenoInstituto de Investigación en Ciencias de la Alimentación, CIAL (CSIC-UAM), Madrid, Spain.
Tilemachos GoumperisEuropean Food Safety Authority (EFSA), Parma, Italy.
Michele ArdizzoneEuropean Food Safety Authority (EFSA), Parma, Italy.
Reinhilde SchoonjansEuropean Food Safety Authority (EFSA), Parma, Italy.
Ian DewhurstFormerly at Chemicals Regulation Division (CRD), York, United Kingdom.
Ivan DimitrovMedical University of Sofia, Sofia, Bulgaria.
Michelle M EpsteinLaboratory of Experimental Allergy, Department of Dermatology, Medical University of Vienna, Vienna, Austria.
Frits KoningLeiden University Medical Center, Leiden, Netherlands.
Kevin HogeveenAgence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Maisons Alfort, France.
Antonio Fernández-DumontEuropean Food Safety Authority (EFSA), Parma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The European Food Safety Authority (EFSA) carries out safety assessments of newly expressed proteins (NEPs) in genetically modified organisms (GMOs). Here, toxicity and allergenicity assessments are the cornerstone of NEP evaluation, ensuring that any potential health hazards are rigorously identified and characterised. Recent examples of EFSA's NEP safety assessments illustrate how novel methodologies, alongside established ones reconsidered from new perspectives, guide case-by-case decisions. These advances provide an opportunity to improve the robustness, proportionality, and scientific credibility of risk assessments. Moreover, it may alleviate the need for

Indexed as

3RsGMOnew approach methodologiesnewly expressed proteinsprotein safetyrisk assessment

Identifiers

PMID41159064
PMCPMC12554703

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.