ArticleJournal of biomedical optics2025
Development and clinical validation of a clinically translatable non-chip-on-tip transvaginal imaging system (GynoSight v2.0) for early detection of premalignant cervical lesions.
Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Significance: Cervical cancer is the fourth most common cancer among women globally. Hence, it is crucial to develop a noninvasive and portable optical imaging modality for the early detection of premalignant cervical lesions. Aim: We present the development and clinical validation of GynoSight v2.0, an indigenously developed multispectral, non-chip-on-tip source, hand-held, portable transvaginal imaging probe, for evaluating tissue health and identifying anomalies, such as those linked to precancerous cervical lesions. Approach: GynoSight v2.0 houses a 16 LEDs, 5-megapixel camera, and a Raspberry Pi 5 module. A comparative shadowing effect analysis was performed between GynoSight v2.0 and colposcopy by evaluating statistical metrics such as mean pixel intensity (MPI), shadow area percentage (SAP), entropy, and contrast-to-noise ratio. In addition, the relative oxygen saturation maps of the cervical tissue were computed from the multispectral registered image using the proposed discrete Fourier transform-based image registration technique. Results: The images of Conclusions: The colposcopy images showed more shadowing effects than the GynoSight v2.0 images and hence provide better illumination to aid in better diagnosis.
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