ArticleJHEP reports : innovation in hepatology2025
Overt hepatic encephalopathy after elective and preemptive TIPS: Risk factors and prognosis.
Article in JHEP reports : innovation in hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Fluoroscopic quantification of early in vivo expansion of VIATORR controlled expansion stent-grafts after TIPS: hemodynamic and clinical implications.Abdominal radiology (New York) · 2026Article
- Reducing the Risk of Overt Hepatic Encephalopathy Recurrence: A Narrative Review.Journal of clinical and translational hepatology · 2026Review
- Beyond left versus right: from puncture site selection to clinical strategy in TIPS.Hepatology international · 2026Article
- Animal naming test at discharge is associated with hepatic encephalopathy after elective TIPS.JHEP reports : innovation in hepatology · 2026Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background & Aims: Overt hepatic encephalopathy (OHE) develops in 30-50% of patients after transjugular intrahepatic portosystemic shunt (TIPS) placement, depending on patient characteristics and TIPS indication. Data on OHE after preemptive TIPS (pTIPS) are limited. We aimed to assess the prevalence of OHE after pTIPS, to compare OHE after pTIPS and elective TIPS, and to identify risk factors for OHE in each clinical situation. Methods: We performed a single-center observational study of consecutive patients with cirrhosis treated with pTIPS or elective TIPS between 2017 and 2023. Patients were followed until 1 year, death, or liver transplantation (LT). Results: A total of 191 patients were included (pTIPS 85, elective TIPS 106). Patients treated with pTIPS were significantly younger (53 Conclusion: OHE occurs frequently after TIPS, in elective as well as urgent indications. Risk factors for OHE differ in these situations. Persistent OHE after pTIPS and OHE after elective TIPS are associated with poor outcomes and should prompt early discussion of LT candidacy. Impact and implications: This study demonstrates that overt hepatic encephalopathy (OHE) remains a frequent complication after both preemptive and elective transjugular intrahepatic portosystemic shunt (TIPS) placement, though the underlying risk factors differ depending on the clinical indication. Identifying predictors such as cardiac disease, sarcopenia, and baseline ammonia can help refine patient selection and post-TIPS management. The association between OHE and adverse outcomes highlights the need for closer surveillance and timely intervention. Early referral for liver transplantation should be considered in patients who develop persistent or refractory OHE after TIPS.
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Registered trials
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