Evidence map›Paper›PMID 41159042›Full record

ArticleBiomedical reports2025

High glucose promotes cisplatin chemoresistance in MDA-MB-231 breast cancer derived cells through changes in gene expression and multiple signaling pathways.

Araceli Rubí Viedma-Rodríguez, María Guadalupe Martínez-Hernández, Luis Antonio Flores-López, Miguel Ángel Velázquez-Flores, Ruth Ruiz Esparza-Garrido, Javier Rodrigo Prado-Baeza, Luis Arturo Baiza-Gutman

Abstract read
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In one paragraph

Article in Biomedical reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Araceli Rubí Viedma-RodríguezUnit of Morphology and Function, Faculty of Higher Studies-Iztacala, National Autonomous University of Mexico, Tlalnepantla, State of Mexico 54090, Mexico.
María Guadalupe Martínez-HernándezUnit of Morphology and Function, Faculty of Higher Studies-Iztacala, National Autonomous University of Mexico, Tlalnepantla, State of Mexico 54090, Mexico.
Luis Antonio Flores-LópezSecretary of Science, Humanities, Technology and Innovation, National Institute of Pediatrics, Ministry of Health, Mexico City 04530, Mexico.
Miguel Ángel Velázquez-FloresNon-coding RNAs Laboratory, Medical Research Unit in Human Genetics, Children's Hospital 'Dr. Silvestre Frenk Freund', National Medical Center XXI Century, Mexican Institute of Social Security, Ciudad 06720, Mexico.
Ruth Ruiz Esparza-GarridoResearchers for Mexico Program, Non-coding RNAs Laboratory, Medical Research Unit in Human Genetics, Children's Hospital 'Dr. Silvestre Frenk Freund', National Medical Center XXI Century, Mexican Institute of Social Security, Ciudad 06720, Mexico.
Javier Rodrigo Prado-BaezaNational Cancer Institute of Mexico, Mexico City 14080, Mexico.
Luis Arturo Baiza-GutmanUnit of Morphology and Function, Faculty of Higher Studies-Iztacala, National Autonomous University of Mexico, Tlalnepantla, State of Mexico 54090, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epidemiological and experimental evidence indicate that hyperglycemia, transient hyperinsulinemia and insulin-like growth factor-1 promote an aggressive phenotype of breast tumor cells during diabetes mellitus. The present study evaluated the effect of high glucose (HG) concentration (30 mmol/l) on cisplatin sensitivity and gene expression in MDA-MB-231 triple-negative breast cancer (TNBC)-derived cells. Cisplatin cytotoxicity was assessed by the MTT assay and was attenuated by HG. This effect was accompanied by reduced caspase-3 activation, indicating impaired apoptosis. Differentially expressed genes between HG and normal glucose (5.6 mmol/l) conditions were analyzed by microarray. The upregulation of tetraspanin 1 (

Indexed as

breast cancercell deathhyperglycemiatriple-negative breast cancerWnt/β-catenin

Identifiers

PMID41159042
PMCPMC12555112

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.